IS LATE-LIFE CALORIC RESTRICTION BENEFICIAL

被引：41

作者：

LIPMAN, RD

SMITH, DE

BRONSON, RT

机构：

[1] USDA Human Nutrition Research Center on Aging, Tufts University, Boston, Massachusetts, 02111

来源：

AGING-CLINICAL AND EXPERIMENTAL RESEARCH | 1995年 / 7卷 / 02期

关键词：

AGING; CALORIC RESTRICTION; MORTALITY; RATS;

D O I：

10.1007/BF03324303

中图分类号：

R592 [老年病学]; C [社会科学总论];

学科分类号：

03 ; 0303 ; 100203 ;

摘要：

Caloric restriction initiated in young mice and rats results in increases in mean and median life span. When caloric restriction is implemented in older animals, an increase in life span is still observed; however, the magnitude of the increase is not as great as that observed in animals calorie restricted since they were young. Here we report the results of a pilot study in which caloric restriction was initiated in mature, older rats. Survival rates and terminal pathology were characterized and compared between a cohort of 17 continually ad libitum fed Long Evans rats and a cohort of 18 Long Evans rats, which were gradually introduced to 33% restriction in diet consumption at 18 months of age. No difference in the median life span was observed between the two groups. The data suggest there may be a level of maturity, or a stage in the aging process, after which caloric restriction no longer increases longevity.

引用

页码：136 / 139

页数：4

共 12 条

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