CELLULAR UPTAKE AND PHOTOSENSITIZING PROPERTIES OF ANTICANCER PORPHYRINS IN CELL-MEMBRANES AND LOW AND HIGH-DENSITY LIPOPROTEINS

被引：79

作者：

MAZIERE, JC

SANTUS, R

MORLIERE, P

REYFTMANN, JP

CANDIDE, C

MORA, L

SALMON, S

MAZIERE, C

GATT, S

DUBERTRET, L

机构：

[1] MUSEUM NATL HIST NAT,INSERM,U312,PHYSICOCHIM ADAPTAT BIOL LAB,F-75231 PARIS 05,FRANCE

[2] HOP HENRI MONDOR,INSERM,U312,RECH DERMATOL LAB,F-94010 CRETEIL,FRANCE

[3] HEBREW UNIV JERUSALEM,HADASSAH MED SCH,IL-91010 JERUSALEM,ISRAEL

来源：

JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY B-BIOLOGY | 1990年 / 6卷 / 1-2期

关键词：

Anticancer porphyrins; high density lipoprotein (HDL); low density lipoprotein (LDL); membrane; photosensitization;

D O I：

10.1016/1011-1344(90)85074-7

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The mechanisms of the phototoxic effect of anticancer porphyrins used in the photodynamic therapy (PDT) of tumours are not yet completely understood. Irradiation of porphyrins gives rise to singlet oxygen which reacts with key residues of proteins, polyunsaturated fatty acids and cholesterol in membranes, leading to inactivation of various enzymes and transporters. Lipoproteins, mainly low density lipoproteins (LDL), are efficient carriers of anticancer porphyrins in blood and can deliver these photosensitizers to tissues through the apolipoprotein (apo) B/E specific LDL receptor pathway. In this review, we discuss some aspects of anticancer porphyrin transport, cellular uptake and photosensitizing properties in cell membranes and lipoproteins. © 1990.

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页码：61 / 68

页数：8

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