DIRECT ENANTIOMERIC SEPARATION OF TERFENADINE AND ITS MAJOR ACID METABOLITE BY HIGH-PERFORMANCE LIQUID-CHROMATOGRAPHY, AND THE LACK OF STEREOSELECTIVE TERFENADINE ENANTIOMER BIOTRANSFORMATION IN MAN

被引：19

作者：

CHAN, KY

GEORGE, RC

CHEN, TM

OKERHOLM, RA

机构：

[1] Marion Merrell Dow Inc., Cincinnati, OH 45215-6300

来源：

JOURNAL OF CHROMATOGRAPHY-BIOMEDICAL APPLICATIONS | 1991年 / 571卷 / 1-2期

关键词：

D O I：

10.1016/0378-4347(91)80458-O

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

Direct enantiomeric separation of terfenadine and its major acid metabolite was achieved by using two different chiral stationary phase columns with two different mobile phase systems. Further, the enantiomeric composition of the human urinary acid metabolite has been determined, indicating a non-stereoselective biotransformation in man.

引用

页码：291 / 297

页数：7

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