INTERACTION BETWEEN TUMOR-NECROSIS-FACTOR-ALPHA AND HSP-70 IN HUMAN LEUKEMIA-CELLS

被引：11

作者：

MULLER, E

MUNKER, R

ISSELS, R

WILMANNS, W

机构：

[1] UNIV MUNICH,KLINIKUM GROSSHADERN,MED KLIN 3,W-8000 MUNICH 70,GERMANY

[2] UNIV MUNICH,KLINIKUM GROSSHADERN,GSF INST KLIN HAMATOL,W-8000 MUNICH 70,GERMANY

来源：

LEUKEMIA RESEARCH | 1993年 / 17卷 / 06期

关键词：

TUMOR NECROSIS FACTOR; HEAT SHOCK PROTEINS; HUMAN LEUKEMIA CELLS;

D O I：

10.1016/0145-2126(93)90128-8

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

We confirm here by immunoblotting that a cell line resistant to clonal inhibition from tumor necrosis factor (K562) expresses high levels of HSP 70, whereas two sensitive cell lines (HL60 blast and EM3) express low levels. When sensitive cell lines are exposed to tumor necrosis factor, HSP 70 is not generally induced; when tumor necrosis factor is removed, however, HSP 70 is transiently induced. In five bone marrow samples from patients, generally low levels of HSP 70 were detected.

引用

页码：523 / 526

页数：4

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