MURAMYLDIPEPTIDE AND GRANULOCYTE-MACROPHAGE COLONY-STIMULATING FACTOR ENHANCE INTERFERON-GAMMA-INDUCED NITRIC-OXIDE PRODUCTION BY RAT ALVEOLAR MACROPHAGES

被引：18

作者：

JORENS, PG

VANOVERVELD, FJ

BULT, H

VERMEIRE, PA

HERMAN, AG

机构：

[1] UNIV INSTELLING ANTWERP,DEPT RESP MED,UNIV PLEIN 1,B-2610 WILRIJK,BELGIUM

[2] UNIV INSTELLING ANTWERP,DEPT PHARMACOL,B-2610 WILRIJK,BELGIUM

来源：

AGENTS AND ACTIONS | 1993年 / 38卷 / 1-2期

关键词：

D O I：

10.1007/BF02027220

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Rat alveolar macrophages incubated with recombinant rat interferon-gamma produce L-arginine-dependent nitric oxide, which is rapidly decomposed into nitrite: this production by interferon-gamma was markedly enhanced by granulocyte-macrophage colony-stimulating factor and muramyldipeptide, but not by other cytokines. The enhancement was dependent on the presence of L-arginine in the incubation medium. It was based on a simple synergism between interferon-gamma and muramyldipeptide and a priming effect of granulocyte-macrophage colony-stimulating factor for interferon-gamma-induced nitrite production. These data suggest that cytokine networks are important in the induction of nitric oxide in rat alveolar macrophages.

引用

页码：100 / 105

页数：6

共 25 条

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