CUTANEOUS PHEOHYPHOMYCOSIS CAUSED BY A RARE FUNGAL PATHOGEN, HORMONEMA-DEMATIOIDES - SUCCESSFUL TREATMENT WITH KETOCONAZOLE

Annular, fungating, ulcerated lesions developed on both hands of a 64-year-old immunocompetent man 2 months after he was cut with barbed wire. A dematiaceous mold, Hormonema dematioides, heretofore not definitively associated with human disease, was grown from two separate tissue specimens during a period of 9 days. Histopathologic examination demonstrated rare small, periodic acid-Schiff-positive, hyaline, yeastlike organisms in tissue. Twelve weeks of empiric therapy with ketoconazole, 400 mg/day, was curative. © 1990, American Academy of Dermatology, Inc.. All rights reserved.