PERIPHERAL ACTION OF SPIRONOLACTONE - PLETHYSMOGRAPHIC STUDIES

被引：6

作者：

CLEMENT, DL ^{[1
]}

机构：

[1] STATE UNIV GHENT,DEPT CARDIOVASC DIS,B-9000 GHENT,BELGIUM

来源：

AMERICAN JOURNAL OF CARDIOLOGY | 1990年 / 65卷 / 23期

关键词：

D O I：

10.1016/0002-9149(90)91269-C

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The relation between vasodilation and the blood pressure-reducing action of spironolactone was studied in a randomized, placebo-controlled, double-blind, crossover study using 9 patients with essential hypertension. Vasodilation was studied by measuring Mood flow in finger and calf (representative of skin and muscle circulation) by an etectrocardiographic-triggered venous-occlusion plethysmograph. Treatment with spironolactone (100 mg twice daily for 4 weeks) produced significant decreases in systolic and diastolic blood pressure without significantly affecting heart rate. Blood flow through finger and calf increased, sometimes markedly, in 6 of the 9 patients, while vascular resistance decreased. This study confirms that the antihypertensive action of spironolactone is associated with vasodilation in many patients. © 1990.

引用

页码：K12 / K13

页数：2