A NOVEL ADENYLYL CYCLASE-ACTIVATING SEROTONIN RECEPTOR (5-HT7) IMPLICATED IN THE REGULATION OF MAMMALIAN CIRCADIAN-RHYTHMS

被引：649

作者：

LOVENBERG, TW

BARON, BM

DELECEA, L

MILLER, JD

PROSSER, RA

REA, MA

FOYE, PE

RACKE, M

SLONE, AL

SIEGEL, BW

DANIELSON, PE

SUTCLIFFE, JG

ERLANDER, MG

机构：

[1] MARION MERRELL DOW RES INST, CINCINNATI, OH 45215 USA

[2] STANFORD UNIV, MED CTR, SCH MED, CTR SLEEP & CIRCADIAN NEUROBIOL, STANFORD, CA 94305 USA

[3] ARMSTRONG LAB, CIRCADIAN NEUROBIOL RES GRP, BROOKS AFB, TX 78235 USA

来源：

NEURON | 1993年 / 11卷 / 03期

关键词：

D O I：

10.1016/0896-6273(93)90149-L

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

We report the cloning and characterization of a novel serotonin receptor, designated as 5-HT7, which is coupled to the stimulation of adenylyl cyclase. 5-HT7 mRNA is expressed discretely throughout the CNS, predominantly in the thalamus and hypothalamus. 5-HT7 has a unique pharmacological profile that redefines agonist and antagonist classification of ligands previously thought to be ''selective.'' The circadian phase of spontaneous neuronal activity of the rat suprachiasmatic nucleus of the hypothalamus advances in response to serotonin ligands with a pharmacological profile consistent exclusively with that of 5-HT7. These findings suggest a physiological role in the regulation of circadian rhythms for one subtype of serotonin receptor, 5-HT7, and provide a pharmacological test to evaluate its role in other neuronal systems.

引用

页码：449 / 458

页数：10

共 52 条

[1] CLONING OF ANOTHER HUMAN SEROTONIN RECEPTOR (5-HT1F) - A 5TH 5-HT1 RECEPTOR SUBTYPE COUPLED TO THE INHIBITION OF ADENYLATE-CYCLASE [J].