EFFECT OF INGESTION OF 20 PESTICIDES IN COMBINATION AT ACCEPTABLE DAILY INTAKE LEVELS ON RAT-LIVER CARCINOGENESIS

被引：25

作者：

ITO, N ^{[1
]}

HASEGAWA, R ^{[1
]}

IMAIDA, K ^{[1
]}

KURATA, Y ^{[1
]}

HAGIWARA, A ^{[1
]}

SHIRAI, T ^{[1
]}

机构：

[1] NAGOYA CITY UNIV,SCH MED,DEPT PATHOL 1,MIZUHO KU,NAGOYA,AICHI 467,JAPAN

来源：

FOOD AND CHEMICAL TOXICOLOGY | 1995年 / 33卷 / 02期

关键词：

D O I：

10.1016/0278-6915(94)00118-8

中图分类号：

TS2 [食品工业];

学科分类号：

0832 ;

摘要：

Exposure of agricultural workers and the general population to pesticides is a major concern, and possible summation or synergistic effects deserves particular attention. In this study, however, combined dietary administration of 19 organophosphorus compounds and one organochlorine pesticide, each at acceptable daily intake (ADI) levels, did not enhance rat liver preneoplastic lesion development initiated by diethylnitrosamine. In contrast, a mixture of 100 times ADI significantly increased the number and area of lesions. The results thus provide direct support for the present safety factor approach to the quantitative hazard evaluation of pesticides.

引用

页码：159 / 163

页数：5

共 33 条

[1] PRENEOPLASTIC LESIONS AS END-POINTS IN CARCINOGENICITY TESTING .1. HEPATIC PRENEOPLASIA [J].

BANNASCH, P .

CARCINOGENESIS, 1986, 7 (05) :689-695

[2] A RAPID INVIVO BIOASSAY FOR THE CARCINOGENICITY OF PESTICIDES [J].

CABRAL, R ;

HOSHIYA, T ;

HAKOI, K ;

HASEGAWA, R ;

FUKUSHIMA, S ;

ITO, N .

TUMORI, 1991, 77 (03) :185-188

[3] ANALYSIS OF CARCINOGENIC ACTIVITY OF SOME PESTICIDES IN A MEDIUM-TERM LIVER BIOASSAY IN THE RAT [J].

HAKOI, K ;

CABRAL, R ;

HOSHIYA, T ;

HASEGAWA, R ;

SHIRAI, T ;

ITO, N .

TERATOGENESIS CARCINOGENESIS AND MUTAGENESIS, 1992, 12 (06) :269-276

[4]

HASEGAWA R, 1993, INT J CANCER, V54, P489

[5] LIVER MEDIUM-TERM BIOASSAY IN RATS FOR SCREENING OF CARCINOGENS AND MODIFYING FACTORS IN HEPATOCARCINOGENESIS [J].

HASEGAWA, R ;

ITO, N .

FOOD AND CHEMICAL TOXICOLOGY, 1992, 30 (11) :979-+

[6] SYNERGISTIC ENHANCEMENT OF GLUTATHIONE-S-TRANSFERASE PLACENTAL FORM-POSITIVE HEPATIC FOCI DEVELOPMENT IN DIETHYLNITROSAMINE-TREATED RATS BY COMBINED ADMINISTRATION OF 5 HETEROCYCLIC AMINES AT LOW-DOSES [J].

HASEGAWA, R ;

SHIRAI, T ;

HAKOI, K ;

TAKABA, K ;

IWASAKI, S ;

HOSHIYA, T ;

ITO, N ;

NAGAO, M ;

SUGIMURA, T .

JAPANESE JOURNAL OF CANCER RESEARCH, 1991, 82 (12) :1378-1384

[7] SYNERGISTIC ENHANCEMENT OF HEPATIC FOCI DEVELOPMENT BY COMBINED TREATMENT OF RATS WITH 10 HETEROCYCLIC AMINES AT LOW-DOSES [J].

HASEGAWA, R ;

MIYATA, E ;

FUTAKUCHI, M ;

HAGIWARA, A ;

NAGAO, M ;

SUGIMURA, T ;

ITO, N .

CARCINOGENESIS, 1994, 15 (05) :1037-1041

[8]

HIROSE M, 1993, CANCER RES, V53, P32

[9] ENHANCEMENT BY NONMUTAGENIC PESTICIDES OF GST-P POSITIVE HEPATIC FOCI DEVELOPMENT INITIATED WITH DIETHYLNITROSAMINE IN THE RAT [J].

HOSHIYA, T ;

HASEGAWA, R ;

HAKOI, K ;

CUI, L ;

OGISO, T ;

CABRAL, R ;

ITO, N .

CANCER LETTERS, 1993, 72 (1-2) :59-64

[10] ADVANTAGES AND LIMITATIONS OF STEREOLOGICAL ESTIMATION OF PLACENTAL GLUTATHIONE S-TRANSFERASE-POSITIVE RAT-LIVER CELL FOCI BY COMPUTERIZED 3-DIMENSIONAL RECONSTRUCTION [J].

IMAIDA, K ;

TATEMATSU, M ;

KATO, T ;

TSUDA, H ;

ITO, N .

JAPANESE JOURNAL OF CANCER RESEARCH, 1989, 80 (04) :326-330

← 1 2 3 4 →