M-CHLOROPHENYLPIPERAZINE DECREASES FOOD-INTAKE IN A TEST MEAL

被引：70

作者：

WALSH, AES ^{[1
]}

SMITH, KA ^{[1
]}

OLDMAN, AD ^{[1
]}

WILLIAMS, C ^{[1
]}

GOODALL, EM ^{[1
]}

COWEN, PJ ^{[1
]}

机构：

[1] LITTLEMORE HOSP,PSYCHOPHARMACOL RES UNIT,OXFORD OX4 4XN,ENGLAND

来源：

PSYCHOPHARMACOLOGY | 1994年 / 116卷 / 01期

基金：

英国惠康基金;

关键词：

FOOD INTAKE; 5-HT RECEPTORS; M-CHLOROPHENYLPIPERAZINE;

D O I：

10.1007/BF02244883

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

We studied the effect of the 5-HT receptor agonist, m-chlorophenylpiperazine (mCPP) (0.4 mg/kg), on food intake in 12 healthy female volunteers, in a double-blind placebo controlled design. Compared to placebo, mCPP significantly lowered food intake in a test meal. Treatment with mCPP also caused significant increases in ratings of nausea and light-headedness, though these effects had remitted by the time of the test meal. The results suggest that activation of brain 5-HT2C receptors may lower food intake in humans; it is also possible, however, that the hypophagic effect of mCPP in the present study could be a consequence of its adverse subjective side effects.

引用

页码：120 / 122

页数：3

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