GENDER DIFFERENCES IN INSULIN-STIMULATED GLUCOSE-UTILIZATION AMONG AFRICAN-AMERICANS

被引：32

作者：

FALKNER, B

HULMAN, S

KUSHNER, H

机构：

[1] Departments of Pediatrics and Medicine, Medical College of Pennsylvania, Philadelphia, PA

来源：

AMERICAN JOURNAL OF HYPERTENSION | 1994年 / 7卷 / 11期

关键词：

AFRICAN-AMERICANS; WOMEN; INSULIN; BLOOD PRESSURE; ANDROGENS; ESTROGEN;

D O I：

10.1093/ajh/7.11.948

中图分类号：

R6 [外科学];

学科分类号：

1002 ; 100210 ;

摘要：

The purpose of this study was to determine whether there are gender differences in plasma insulin levels or insulin resistance in young adult African-Americans. Male (n = 53) and female (n = 45) subjects (age 23 to 28 years) included normotensives (N, blood pressure [BP] < 135/85 mm Hg) and borderline hypertensives (BH, BP > 135/85 mm Hg). Plasma insulin concentration was measured during an oral glucose tolerance test (OGTT) in all subjects. In 50 cases, insulin clamps were performed. Plasma estradiol and free testosterone were analyzed in a subsample (n = 15) of women. Data were analyzed for BP and gender groups by two-way ANOVA. Compared to men, women in each BP group had higher plasma insulin: glucose ratios (P < .01) and sums of insulin on OGTT (P < .02). The insulin clamp data also demonstrated significantly lower insulin-stimulated glucose utilization (M) in women compared to men in each BP group (N males 7.28 +/- 0.72 v N females 4.94 +/- 1.2 mg/kg-min; BH males 5.28 +/- .56 v BH females 2.59 +/- 0.50 mg/kg-min; P < .004 for gender differences). Analysis of the sex hormone data found a significant correlation in the ratio of free testosterone/estradiol (T/E) with plasma glucose, insulin, insulin/glucose, and systolic BP (P < .05), and no correlation of T/E with body mass index or triceps skinfold thickness. These data indicate that there are significant gender differences in plasma insulin levels and in insulin sensitivity in African-Americans. The relationship of plasma insulin to sex hormones suggests that in females, hyperinsulinemia cosegregates with increased androgenicity.

引用

页码：948 / 952

页数：5

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