THE G-PROTEIN-GATED ATRIAL K+ CHANNEL I-KACH IS A HETEROMULTIMER OF 2 INWARDLY RECTIFYING K+-CHANNEL PROTEINS

被引：760

作者：

KRAPIVINSKY, G ^{[1
]}

GORDON, EA ^{[1
]}

WICKMAN, K ^{[1
]}

VELIMIROVIC, B ^{[1
]}

KRAPIVINSKY, L ^{[1
]}

CLAPHAM, DE ^{[1
]}

机构：

[1] MAYO CLIN & MAYO FDN,DEPT PHARMACOL,ROCHESTER,MN 55905

来源：

NATURE | 1995年 / 374卷 / 6518期

关键词：

D O I：

10.1038/374135a0

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Heart rate is slowed in part by acetylcholine-dependent activation of a cardiac potassium (K+) channel, I-KACh. Activated muscarinic receptors stimulate I-KACh via the G-protein beta gamma-subunits. It has been assumed that the inwardly rectifying K+-channel gene, GIRK1, alone encodes I-KACh. It is now shown that I-KACh is a heteromultimer of two distinct inwardly rectifying K+-channel subunits, GIRK1 and a newly cloned member of the family, CIR.

引用

页码：135 / 141

页数：7

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