Galectin-3 as a Potential Target to Prevent Cancer Metastasis

被引：97

作者：

Ahmed, Hafiz ^{[1
]}

AlSadek, Dina M. M. ^{[2
]}

机构：

[1] GlycoMantra Inc, Aldie, VA 20105 USA

[2] Zagazig Univ, Dept Histol & Cytol, Zagazig, Egypt

来源：

CLINICAL MEDICINE INSIGHTS-ONCOLOGY | 2015年 / 9卷

关键词：

galectin-3; angiogenesis; apoptosis; tumorigenesis; TF disaccharide;

D O I：

10.4137/CMO.S29462

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 [肿瘤学];

摘要：

Interactions between two cells or between cell and extracellular matrix mediated by protein-carbohydrate interactions play pivotal roles in modulating various biological processes such as growth regulation, immune function, cancer metastasis, and apoptosis. Galectin-3, a member of the beta-galactoside-binding lectin family, is involved in fibrosis as well as cancer progression and metastasis, but the detailed mechanisms of its functions remain elusive. This review discusses its structure, carbohydrate-binding properties, and involvement in various aspects of tumorigenesis and some potential carbohydrate ligands that are currently investigated to block galectin-3 activity.

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收藏

页码：113 / 121

页数：9

相关论文

共 147 条

[1]

Potential roles of galectins in myeloid differentiation into three different lineages [J].

Abedin, MJ ;

Kashio, Y ;

Seki, M ;

Nakamura, K ;

Hirashima, M .

JOURNAL OF LEUKOCYTE BIOLOGY, 2003, 73 (05) :650-656

[2]

HUMAN SPLENIC GALAPTIN - CARBOHYDRATE-BINDING SPECIFICITY AND CHARACTERIZATION OF THE COMBINING SITE [J].

AHMED, H ;

ALLEN, HJ ;

SHARMA, A ;

MATTA, KL .

BIOCHEMISTRY, 1990, 29 (22) :5315-5319

[3]

Ahmed H, 1996, J BIOCHEM, V120, P1007

[4]

Biochemical and molecular characterization of galectins from zebrafish (Danio rerio):: notochord-specific expression of a prototype galectin during early embryogenesis [J].

Ahmed, H ;

Du, SJ ;

O'Leary, N ;

Vasta, GR .

GLYCOBIOLOGY, 2004, 14 (03) :219-232

[5]

The primary structure and carbohydrate specificity of a beta-galactosyl-binding lectin from toad (Bufo arenarum Hensel) ovary reveal closer similarities to the mammalian galectin-1 than to the galectin from the clawed frog Xenopus laevis [J].

Ahmed, H ;

Pohl, J ;

Fink, NE ;

Strobel, F ;

Vasta, GR .

JOURNAL OF BIOLOGICAL CHEMISTRY, 1996, 271 (51) :33083-33094

[6]

GALECTINS - CONSERVATION OF FUNCTIONALLY AND STRUCTURALLY RELEVANT AMINO-ACID-RESIDUES DEFINES 2 TYPES OF CARBOHYDRATE-RECOGNITION DOMAINS [J].

AHMED, H ;

VASTA, GR .

GLYCOBIOLOGY, 1994, 4 (05) :545-548

[7]

Differential expression of galectins in normal, benign and malignant prostate epithelial cells: Silencing of galectin-3 expression in prostate cancer by its promoter methylation [J].

Ahmed, Hafiz ;

Banerjee, Partha P. ;

Vasta, Gerardo R. .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2007, 358 (01) :241-246

[8]

Ahmed Hafiz, 2010, Biomark Cancer, V2, P17, DOI 10.4137/BIC.S3187

[9]

Evidence of Heavy Methylation in the Galectin 3 Promoter in Early Stages of Prostate Adenocarcinoma: Development and Validation of a Methylated Marker for Early Diagnosis of Prostate Cancer [J].

Ahmed, Hafiz ;

Cappello, Francesco ;

Rodolico, Vito ;

Vasta, Gerardo R. .

TRANSLATIONAL ONCOLOGY, 2009, 2 (03) :146-156

[10]

Akahani S, 1997, CANCER RES, V57, P5272

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