EFFECT OF ACYLATION STIMULATING PROTEIN ON THE TRIACYLGLYCEROL SYNTHETIC PATHWAY OF HUMAN ADIPOSE-TISSUE

被引：117

作者：

YASRUEL, Z ^{[1
]}

CIANFLONE, K ^{[1
]}

SNIDERMAN, AD ^{[1
]}

ROSENBLOOM, M ^{[1
]}

WALSH, M ^{[1
]}

RODRIGUEZ, MA ^{[1
]}

机构：

[1] MCGILL UNIV,ROYAL VICTORIA HOSP,MCGILL UNIT PREVENT CARDIOVASC DIS,MONTREAL H3A 1A1,QUEBEC,CANADA

来源：

LIPIDS | 1991年 / 26卷 / 07期

关键词：

D O I：

10.1007/BF02536592

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Acylation stimulating protein (ASP) is a 14 kDa plasma protein which causes in vitro triacylglycerol synthesis in human adipocytes and fibroblasts to increase substantially. ASP was found to stimulate human adipose tissue microsomal glycerophosphate acyltransferase and diacylglycerol acyltransferase activities by 23% and 90%, respectively. However, phosphatidate phosphohydrolase activity showed no increase in activity, nor did microsomal acyl-CoA synthetase activity. Moreover, ASP did not decrease the apparent K(m) of diacylglycerol acyltransferase (DGAT), but rather increased its apparent V(max) suggesting direct interaction of ASP with DGAT.

引用

页码：495 / 499

页数：5

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