EFFECTS ON CYCLOOXYGENASE OF LOW AND HIGH-DOSE ASPIRIN

被引:5
作者
BEVING, H
EKSBORG, S
NORDLANDER, R
OLSSON, P
OLSSON, U
机构
[1] KAROLINSKA HOSP,KAROLINSKA PHARM,RES DEPT,S-10401 STOCKHOLM 60,SWEDEN
[2] KAROLINSKA HOSP,DEPT MED,DIV CARDIOL,THORAC CLIN,S-10401 STOCKHOLM 60,SWEDEN
关键词
12-hydroxyheptadecatrienoic acid (12-HHT); Acetylsalicylic acid; low dose intake; platelet function; salicylate;
D O I
10.1016/0049-3848(90)90126-W
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
The study was undertaken to develop clinically applicable methods to detect the influence of low dose treatment with acetylsalicylic acid (ASA) on the platelet function. The cyclooxygenase activity of the platelets was measured by determination of the metabolite 12-HHT after challenge with arachidonic acid. Two healthy subjects received 600 mg ASA in a single dose. Two hours after intake the salicylate concentration level in plasma was 600 nmol/ml, with a 90 per cent reduction after 24 hours. The platelet cyclooxygenase activity (12-HHT) was completely and irreversibly inhibited within two hours after ASA intake. Five subjects received 75 mg ASA for eight consecutive days. The salicylate concentrations two hours after the intake of the first and last tablet were within 65 and 71 nmol/ml plasma, indicating that no accumulation of salicylate occurred during the treatment period. The decrease in cyclooxygenase activity during low dose treatment varied in the different subjects between 60 and 90 percent. The rate of recovery of cyclooxygenase activity after termination of the low dose ASA treatment was faster than after the large single dose. © 1990.
引用
收藏
页码:227 / 235
页数:9
相关论文
共 20 条
[1]   DETERMINATION OF PLATELET-MEGAKARYOCYTE REGENERATION TIME IN PAINTERS OCCUPATIONALLY EXPOSED TO ORGANIC-SOLVENTS [J].
BEVING, H ;
KRISTENSSON, J ;
MALMGREN, R ;
OLSSON, U ;
SCHMIDT, S ;
SVENSSON, J .
JOURNAL OF CHROMATOGRAPHY, 1986, 382 :67-77
[2]  
BEVING H, 1990, IN PRESS J CHROM BIO
[3]   AICLA CONTROLLED TRIAL OF ASPIRIN AND DIPYRIDAMOLE IN THE SECONDARY PREVENTION OF ATHERO-THROMBOTIC CEREBRAL-ISCHEMIA [J].
BOUSSER, MG ;
ESCHWEGE, E ;
HAGUENAU, M ;
LEFAUCCONNIER, JM ;
THIBULT, N ;
TOUBOUL, D ;
TOUBOUL, PJ .
STROKE, 1983, 14 (01) :5-14
[4]   EFFECT OF DIPYRIDAMOLE AND ASPIRIN ON LATE VEIN-GRAFT PATENCY AFTER CORONARY-BYPASS OPERATIONS [J].
CHESEBRO, JH ;
FUSTER, V ;
ELVEBACK, LR ;
CLEMENTS, IP ;
SMITH, HC ;
HOLMES, DR ;
BARDSLEY, WT ;
PLUTH, JR ;
WALLACE, RB ;
PUGA, FJ ;
ORSZULAK, TA ;
PIEHLER, JM ;
DANIELSON, GK ;
SCHAFF, HV ;
FRYE, RL .
NEW ENGLAND JOURNAL OF MEDICINE, 1984, 310 (04) :209-214
[5]   IMPROVEMENT IN EARLY SAPHENOUS-VEIN GRAFT PATENCY AFTER CORONARY-ARTERY BYPASS-SURGERY WITH ANTIPLATELET THERAPY - RESULTS OF A VETERANS ADMINISTRATION COOPERATIVE STUDY [J].
GOLDMAN, S ;
COPELAND, J ;
MORITZ, T ;
HENDERSON, W ;
ZADINA, K ;
OVITT, T ;
DOHERTY, J ;
READ, R ;
CHESLER, E ;
SAKO, Y ;
LANCASTER, L ;
EMERY, R ;
SHARMA, GVRK ;
JOSA, M ;
PACOLD, I ;
MONTOYA, A ;
PARIKH, D ;
SETHI, G ;
HOLT, J ;
KIRKLIN, J ;
SHABETAI, R ;
MOORES, W ;
ALDRIDGE, J ;
MASUD, Z ;
DEMOTS, H ;
FLOTEN, S ;
HAAKENSON, C ;
HARKER, LA .
CIRCULATION, 1988, 77 (06) :1324-1332
[6]  
Green K, 1986, Adv Prostaglandin Thromboxane Leukot Res, V16, P309
[7]   METHOD FOR MEASUREMENT OF PLATELET REGENERATION IN MAN [J].
HAMBERG, M ;
SVENSSON, J ;
BLOMBACK, M .
PROSTAGLANDINS AND MEDICINE, 1978, 1 (06) :455-460
[8]   NOVEL ANALGESIC-ANTI-INFLAMMATORY SALICYLATES [J].
HANNAH, J ;
RUYLE, WV ;
JONES, H ;
MATZUK, AR ;
KELLY, KW ;
WITZEL, BE ;
HOLTZ, WJ ;
HOUSER, RA ;
SHEN, TY ;
SARETT, LH ;
LOTTI, VJ ;
RISLEY, EA ;
VANARMAN, CG ;
WINTER, CA .
JOURNAL OF MEDICINAL CHEMISTRY, 1978, 21 (11) :1093-1100
[9]   PREVENTION OF THROMBOSIS IN PATIENTS ON HEMODIALYSIS BY LOW-DOSE ASPIRIN [J].
HARTER, HR ;
BURCH, JW ;
MAJERUS, PW ;
STANFORD, N ;
DELMEZ, JA ;
ANDERSON, CB ;
WEERTS, CA .
NEW ENGLAND JOURNAL OF MEDICINE, 1979, 301 (11) :577-579
[10]  
HENDERSON B, 1986, British Journal of Pharmacology, V88, p400P