CATECHOL-O-METHYLTRANSFERASE-INHIBITING PYROCATECHOL DERIVATIVES - SYNTHESIS AND STRUCTURE-ACTIVITY STUDIES

被引:104
作者
BORGULYA, J [1 ]
BRUDERER, H [1 ]
BERNAUER, K [1 ]
ZURCHER, G [1 ]
DAPRADA, M [1 ]
机构
[1] F HOFFMANN LA ROCHE & CO LTD,DEPT PHARMACEUT RES,CH-4002 BASEL,SWITZERLAND
关键词
D O I
10.1002/hlca.19890720511
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
引用
收藏
页码:952 / 968
页数:17
相关论文
共 38 条
  • [1] Albert, 1984, DETERMINATION IONIZA
  • [2] SYNTHESIS OF SOME NOVEL POTENT AND SELECTIVE CATECHOL O-METHYLTRANSFERASE INHIBITORS
    BACKSTROM, R
    HONKANEN, E
    PIPPURI, A
    KAIRISALO, P
    PYSTYNEN, J
    HEINOLA, K
    NISSINEN, E
    LINDEN, IB
    MANNISTO, PT
    KAAKKOLA, S
    POHTO, P
    [J]. JOURNAL OF MEDICINAL CHEMISTRY, 1989, 32 (04) : 841 - 846
  • [3] BERNAUER K, 1986, Patent No. 980
  • [4] BERNAUER K, 1987, Patent No. 1034690
  • [5] BHATT MV, 1982, SYNTHESIS-STUTTGART, P1048
  • [6] CATECHOL O-METHYLTRANSFERASE .10. 5-SUBSTITUTED 3-HYDROXY-4-METHOXYBENZOIC ACIDS (ISOVANILLIC ACIDS) AND 5-SUBSTITUTED 3-HYDROXY-4-METHOXYBENZALDEHYDES (ISOVANILLINS) AS POTENTIAL INHIBITORS
    BORCHARDT, RT
    HUBER, JA
    HOUSTON, M
    [J]. JOURNAL OF MEDICINAL CHEMISTRY, 1982, 25 (03) : 258 - 263
  • [7] CALNE DB, 1973, CLIN PHARMACOL THER, V14, P386
  • [8] CHABRIER P, 1957, CR HEBD ACAD SCI, V245, P174
  • [9] COLZI A, 1989, EARLY DIAGNOSIS PREV, P191
  • [10] DAPRADA M, 1984, EXPERIENTIA, V40, P1165