INVITRO RELEASE PROFILE OF ESTRADIOL TRANSDERMAL THERAPEUTIC SYSTEMS

被引：18

作者：

TYMES, NW

SHAH, VP

SKELLY, JP

机构：

[1] US FDA,CTR DRUG EVALUAT & RES,ROCKVILLE,MD 20857

[2] BALTIMORE DIST LAB,BALTIMORE,MD 21201

来源：

JOURNAL OF PHARMACEUTICAL SCIENCES | 1990年 / 79卷 / 07期

关键词：

D O I：

10.1002/jps.2600790711

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The in vitro release profiles of two sizes of estradiol patches were determined by the paddle method, where the patch was held in position at the bottom of the dissolution vessel by sandwiching it between a watch glass and an aluminum wire mesh or Teflon screen, and also by the manufacturer's paddle‐over‐disk method. The estradiol content of test aliquots of the dissolution medium was determined by HPLC. The release profiles by both procedures were comparable and showed that ∼10% of the labeled drug was released in 4 days. Copyright © 1990 Wiley‐Liss, Inc., A Wiley Company

引用

页码：601 / 602

页数：2

共 8 条

[1] INVITRO DISSOLUTION PROFILE OF TRANSDERMAL NITROGLYCERIN PATCHES USING PADDLE METHOD [J].