D-ASPARTATE OXIDASE, A PEROXISOMAL ENZYME IN LIVER OF RAT AND MAN

被引：91

作者：

VANVELDHOVEN, PP

BREES, C

MANNAERTS, GP

机构：

来源：

BIOCHIMICA ET BIOPHYSICA ACTA | 1991年 / 1073卷 / 01期

关键词：

PEROXISOME; OXIDASE; DICARBOXYLIC AMINO ACID; ZELLWEGER SYNDROME; EXCITOTOXICITY; (HUMAN LIVER);

D O I：

10.1016/0304-4165(91)90203-S

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

By means of subcellular fractionation D-aspartate oxidase was shown to be localized in peroxisomes in rat and human liver. The oxidase from both sources was most active on D-aspartate and N-methyl-D-aspartate. In different rat tissues, the highest enzyme activity was found in kidney, followed by liver and brain. In these tissues, oxidase activities became detectable 1-4 days after birth, reaching adult values after 4 weeks. Analysis of liver samples from patients with Zellweger syndrome, a generalized peroxisomal dysfunction, demonstrated no significant deficiency of this particular oxidase.

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页码：203 / 208

页数：6

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