PROPERTIES AND FUNCTION OF LYSYL OXIDASE

被引：295

作者：

KAGAN, HM

TRACKMAN, PC

机构：

[1] Department of Biochemistry, Boston University School of Medicine, Massachusetts

来源：

AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY | 1991年 / 5卷 / 03期

关键词：

D O I：

10.1165/ajrcmb/5.3.206

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Lysyl oxidase catalyzes the oxidation of peptidyl lysine to alpha-aminoadipic-delta-semialdehyde, the precursor to the covalent crosslinkages that stabilize fibers of elastin and collagen. This enzyme contains both copper and a carbonyl cofactor consistent with an o-quinone. The proposed mechanism of action is derived from available kinetic and chemical data and also can account for mechanism-based inhibition of the enzyme by specific monoamines and diamines. Recent evidence for biosynthetic precursors and for the regulation of lysyl oxidase in fibrotic and malignant diseases is discussed.

引用

页码：206 / 210

页数：5

共 49 条

[1] AALTO M, 1989, BRIT J EXP PATHOL, V70, P167
[2] ALMASSIAN BJ, 1990, CONNECT TISSUE RES, V25, P197
[3] MICROBIAL-PRODUCTION OF PYRROLOQUINOLINE QUINONE
AMEYAMA, M
HAYASHI, M
MATSUSHITA, K
SHINAGAWA, E
ADACHI, O
[J]. AGRICULTURAL AND BIOLOGICAL CHEMISTRY, 1984, 48 (02): : 561 - 565
[4] LOCALIZATION OF HUMAN PLACENTA LYSYL OXIDASE ON HUMAN PLACENTA, SKIN AND AORTA BY IMMUNOELECTRONMICROSCOPY
BACCARANICONTRI, M
VINCENZI, D
QUAGLINO, D
MORI, G
PASQUALIRONCHETTI, I
[J]. MATRIX, 1990, 9 (06): : 428 - 436
[5] LYSYL OXIDASE - EVIDENCE THAT PYRIDOXAL-PHOSPHATE IS A COFACTOR
BIRD, TA
LEVENE, CI
[J]. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1982, 108 (03) : 1172 - 1180
[6] STIMULATION OF LYSYL OXIDASE (EC 1.4.3.13) ACTIVITY BY TESTOSTERONE AND CHARACTERIZATION OF ANDROGEN RECEPTORS IN CULTURED CALF AORTA SMOOTH-MUSCLE CELLS
BRONSON, RE
CALAMAN, SD
TRAISH, AM
KAGAN, HM
[J]. BIOCHEMICAL JOURNAL, 1987, 244 (02) : 317 - 323
[7] BURBELO PD, 1986, COLLAGEN REL RES, V6, P153
[8] Cleary E.G., 1987, CONNECTIVE TISSUE DI, V12, P55
[9] EXPRESSION OF GENE-RRG IS ASSOCIATED WITH REVERSION OF NIH 3T3 TRANSFORMED BY LTR-C-H-RAS
CONTENTE, S
KENYON, K
RIMOLDI, D
FRIEDMAN, RM
[J]. SCIENCE, 1990, 249 (4970) : 796 - 798
[10] SKIN LYSYL OXIDASE ACTIVITY IS NOT RATE LIMITING FOR COLLAGEN CROSS-LINKING IN THE GLUCOCORTICOID-TREATED RAT
COUNTS, DF
SHULL, S
CUTRONEO, KR
[J]. CONNECTIVE TISSUE RESEARCH, 1986, 14 (03) : 237 - 243

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