DNA-SEQUENCE ANALYSIS AND COMPARISON OF THE VARIABLE HEAVY AND LIGHT CHAIN REGIONS OF 2 IGM, MONOCLONAL, ANTIMYELIN ASSOCIATED GLYCOPROTEIN ANTIBODIES

被引：20

作者：

SPATZ, LA ^{[1
]}

WILLIAMS, M ^{[1
]}

BRENDER, B ^{[1
]}

DESAI, R ^{[1
]}

LATOV, N ^{[1
]}

机构：

[1] COLUMBIA UNIV COLL PHYS & SURG,DEPT NEUROL,NEW YORK,NY 10032

来源：

JOURNAL OF NEUROIMMUNOLOGY | 1992年 / 36卷 / 01期

关键词：

MYELIN-ASSOCIATED GLYCOPROTEIN; AUTOANTIBODY; VARIABLE REGION GENE; PERIPHERAL NEUROPATHY;

D O I：

10.1016/0165-5728(92)90028-J

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The complete variable heavy and light chain gene sequences of two monoclonal, IgM, anti-myelin associated glycoprotein (MAG) antibodies associated with peripheral neuropathy, are presented. Comparative analysis of the two V(H) regions has revealed that they are 88% homologous to one another and are both members of the V(H)3 gene family. They are also highly homologous to a gene which is frequently utilized in the fetal B-cell repertoire. The V(kappa) light chain gene of one of the antibodies is 99% homologous to a V(kappa)II gene and the V(lambda) light chain gene of the other antibody is only 72% homologous to other known V(lambda) genes. Further analysis of V genes utilized by anti-MAG antibodies should reveal the structural basis for their binding activity.

引用

页码：29 / 39

页数：11

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