SONIC SPRAY MASS-SPECTROMETRY

被引:190
作者
HIRABAYASHI, A
SAKAIRI, M
KOIZUMI, H
机构
[1] Central Research Laboratory, Hitachi, Ltd, Tokyo, Kokubunji
关键词
D O I
10.1021/ac00113a023
中图分类号
O65 [分析化学];
学科分类号
070302 ; 081704 ;
摘要
We have developed a sonic spray ionization method, in which a methanol and water solution is sprayed from a fused-silica capillary with gas now coaxial to the capillary. Ions as well as charged droplets are produced under atmospheric pressure, and their intensities depend on the gas now rate (gas velocity). Positive ions produced from dilute solutions of molecules regarded as neurotransmitters, such as catecholamine, by this ionization method have been analyzed with a quadrupole mass spectrometer. The protonated dopamine molecule is detected in the spray of the 10 nM solution, and the mass spectrum is compared with that obtained by the ion spray ionization method. A comparison between the mass-analyzed ion intensity and the ion current, which represents the sum of ions and charged droplets, shows that most ions are produced from the charged droplets after spraying. Furthermore, we found that the charged droplet formation cannot be ascribed to the traditional models of friction electrification, electrical double layer, or statistical charging. An explanation is proposed based on the ion concentration distribution in a small droplet.
引用
收藏
页码:2878 / 2882
页数:5
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