QUALITY-CONTROL IN MANUFACTURING PROCESS BY NEAR-INFRARED SPECTROSCOPY

被引：26

作者：

GONZALEZ, F

POUS, R

机构：

[1] Quality Control Department, Laboratorios Almirall, S.A. Crta. Nacional II, E-08740 Barcelona, Km 593, Sant Andreu de la Barca

来源：

JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS | 1995年 / 13卷 / 4-5期

关键词：

NEAR INFRARED SPECTROSCOPY (NIR); QUALIFICATION; C-PLOT; DISPLOPT; PHARMACEUTICAL; ROUTINE ANALYSIS; PATTERN RECOGNITION TECHNIQUE;

D O I：

10.1016/0731-7085(95)01333-G

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

The combination of a pattern recognition technique with near infrared spectroscopy (NIR) to determine the conformity of a pharmaceutical mixture can be used in the routine checking of a pharmaceutical product. All the chemical and physical characteristics of the product that influence the NIR spectrum affect the qualification. The qualification is used to determine several deviations in the process: moisture, particle size and non-homogeneity. This work presents a method for the qualification analysis of a pharmaceutical mixture using the standard software of the instrument and a new program (DISPLOT). This program allows the acquisition of the plot of the scaled distances with its sign vs the wavelength.

引用

页码：419 / 423

页数：5

共 15 条

[1]

BITTH GS, 1957, AGR MARK, V2, P3

[2] DETERMINATION OF ASCORBIC-ACID IN PHARMACEUTICAL PREPARATIONS BY NEAR-INFRARED REFLECTANCE SPECTROSCOPY [J].

BLANCO, M ;

COELLO, J ;

ITURRIAGA, H ;

MASPOCH, S ;

DELAPEZUELA, C .

TALANTA, 1993, 40 (11) :1671-1676

[3]

BLANCO M, 1992, ELLIS HOR S, P401

[4]

Ciurczak E W., 1986, SPECTROSCOPY-US, V1, P36

[5] USES OF NEAR-INFRARED SPECTROSCOPY IN PHARMACEUTICAL ANALYSIS [J].

CIURCZAK, EW .

APPLIED SPECTROSCOPY REVIEWS, 1987, 23 (1-2) :147-163

[6] DETERMINATION OF 5 COMPONENTS IN A PHARMACEUTICAL FORMULATION USING NEAR-INFRARED REFLECTANCE SPECTROPHOTOMETRY [J].

DUBOIS, P ;

MARTINEZ, JR ;

LEVILLAIN, P .

ANALYST, 1987, 112 (12) :1675-1679

[7]

ILARI JL, 1988, APPL SPECTROSC, V42, P772

[8]

LEONARDI S, 1989, J PHARM BIOMED ANAL, V7, P303

[9]

MARK HL, 1985, ANAL CHEM, V57, P1449, DOI DOI 10.1021/AC00284A061

[10]

Osborne B.G., 1986, NEAR INFRARED SPECTR

← 1 2 →