5H-2-PYRINDINES FROM 2-BROMOCYCLOPENTENE-1-CARBOXALDEHYDE

被引:15
作者
GILCHRIST, TL [1 ]
KEMMITT, PD [1 ]
GERMAIN, AL [1 ]
机构
[1] GLAXO WELLCOME,DARTFORD DA1 5AH,KENT,ENGLAND
基金
英国工程与自然科学研究理事会;
关键词
D O I
10.1016/0040-4020(95)00509-7
中图分类号
O62 [有机化学];
学科分类号
070303 ; 081704 ;
摘要
The palladium(0) catalysed coupling of 2-bromocyclopentene-1-carboxaldehyde N,N'-dimethylhydrazone 1 with vinylzinc halides and with 2-furyl- and 2-thienylzinc halides provides a route to the corresponding 2-vinyl- and 2-heteroaryl-cyclopentene-1-carboxaldehyde dimethylhydrazones. These cyclise thermally to 6,7-dihydro-5H-2-pyrindines (e.g., 3).
引用
收藏
页码:9119 / 9126
页数:8
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