ETHANOL AND SYNAPTOSOMAL CALCIUM HOMEOSTASIS

被引：25

作者：

DAVIDSON, M ^{[1
]}

WILCE, P ^{[1
]}

SHANLEY, B ^{[1
]}

机构：

[1] UNIV QUEENSLAND,DEPT BIOCHEM,ALCOHOL RES UNIT,ST LUCIA,QLD 4067,AUSTRALIA

来源：

BIOCHEMICAL PHARMACOLOGY | 1990年 / 39卷 / 08期

关键词：

D O I：

10.1016/0006-2952(90)90004-5

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The effect of ethanol on synaptosomal calcium homeostasis was studied in the rat using the fluorescent dye, fura-2, and 45Ca uptake. The mitochondrial poison, cyanide, caused a substantial rise in intracellular free Ca2+ concentration, [Ca2+]i, over that of control synaptosomes. This rise was enhanced by ethanol. Ethanol also augmented the rise in [Ca2+]i induced by ouabain, indicating that modulation of Na+-Ca2+ exchange is probably not the underlying mechanism. The Ca2+ channel blockers, verapamil and La3+, also failed to inhibit the rise in [Ca2+]i caused by ethanol. Preincubation of synaptosomes with caffeine, however, caused a significant decrease in the rise of [Ca2+]i due to ethanol, suggesting that ethanol exerts effects on Ca2+ homeostasis at the level of the endoplasmic reticulum. © 1990.

引用

页码：1283 / 1288

页数：6

共 26 条

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