ANXIOGENIC EFFECTS OF A BENZODIAZEPINE RECEPTOR PARTIAL INVERSE AGONIST, RO-19-4603, IN A LIGHT DARK CHOICE SITUATION

被引：19

作者：

BELZUNG, C

MISSLIN, R

VOGEL, E

机构：

[1] Laboratoire de Psychophysiologie, 67000 Strasbourg

来源：

PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR | 1990年 / 36卷 / 03期

关键词：

Convulsions Mice; Ethanol; Inverse agonist of the benzodiazepine receptor; Light/dark choice procedure; RO; 19-4603;

D O I：

10.1016/0091-3057(90)90260-O

中图分类号：

B84 [心理学]; C [社会科学总论]; Q98 [人类学];

学科分类号：

03 ; 0303 ; 030303 ; 04 ; 0402 ;

摘要：

In a light/dark choice procedure, the imidazothienodiazepinone RO 19-4603, given alone, induced a dose-dependent decrease in the time spent by mice in the lit box as well in the number of transitions between the two boxes. These data confirm the anxiogenic intrinsic properties of inverse agonists of the benzodiazepine receptor. Since RO 19-4603 also reversed the anxiolytic effects of ethanol and exhibited proconvulsant properties, it is suggested that the antagonistic action of this drug against ethanol could be due to an additive rather than an interactive process. © 1990.

引用

页码：593 / 596

页数：4

共 30 条

[1] ANXIOGENIC EFFECTS OF METHYL-BETA-CARBOLINE-3-CARBOXYLATE IN A LIGHT DARK CHOICE SITUATION [J].