A NEW FAMILY OF BACTERIAL REGULATORY PROTEINS

被引：148

作者：

HAYDON, DJ ^{[1
]}

GUEST, JR ^{[1
]}

机构：

[1] UNIV SHEFFIELD,KREBS INST,DEPT MOLEC BIOL & BIOTECHNOL,POB 594,FIRTH COURT,SHEFFIELD S10 2UH,ENGLAND

来源：

FEMS MICROBIOLOGY LETTERS | 1991年 / 79卷 / 2-3期

关键词：

HELIX-TURN-HELIX MOTIF; TRANSCRIPTIONAL REGULATOR; DNA-BINDING PROTEIN; SEQUENCE COMPARISON; FADR; GENA; GNTR; HUTC; KORA; P-30; PHNF;

D O I：

10.1016/0378-1097(91)90101-F

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

A new family of bacterial regulatory proteins has been identified by sequence similarity. The family contains the repressor of the Bacillus subtilis gluconate operon (GntR), the regulators for histidine utilization in Pseudomonas putida (HutC(Pp)) and Klebsiella aerogenes (HutC(Ka)), the repressor (FadR) of fatty acid degradation in Escherichia coli, a regulator involved in the conjugal transfer of the broad host range plasmid pIJ101 (KorA), and three proteins of unidentified function in E. coli (GenA. P30 and PhnF). The proteins share amino acid sequence similarities in a 69-residue N-terminal region. A helix-turn-helix motif is predicted in the most highly-conserved segment of each protein suggesting that they are members of a new family of helix-turn-helix DNA-binding proteins.

引用

页码：291 / 296

页数：6

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