SUPPRESSION OF VISUAL-PERCEPTION BY TRANSCRANIAL MAGNETIC STIMULATION - EXPERIMENTAL FINDINGS IN HEALTHY-SUBJECTS AND PATIENTS WITH OPTIC NEURITIS

被引:51
作者
MASUR, H
PAPKE, K
OBERWITTLER, C
机构
[1] Department of Neurology, University of Münster, Münster
来源
ELECTROENCEPHALOGRAPHY AND CLINICAL NEUROPHYSIOLOGY | 1993年 / 86卷 / 04期
关键词
VISUAL PERCEPTION; TRANSCRANIAL MAGNETIC STIMULATION; OPTIC NEURITIS; HUMAN OCCIPITAL CORTEX;
D O I
10.1016/0013-4694(93)90107-7
中图分类号
R318 [生物医学工程];
学科分类号
0831 ;
摘要
The influence of noninvasive magnetic brain stimulation by a magnetic coil (MC) placed over the occiput on perception and correct reporting of a briefly presented set of 3 letters of the alphabet was examined in 15 patients with prolonged VEP latencies due to neuritis of the optic nerve. The results derived from observing these patients were compared to the results obtained from an age-matched control group of 20 healthy voluntary subjects examined under the same experimental conditions. In both groups it was possible to demonstrate that transcranial magnetic stimulation is able to suppress recognition of the letters if applied with a certain delay time after a brief presentation of the visual stimulus. The groups were compared to each other with regard to the delay with which it was possible to demonstrate the most effective suppression. In the healthy subjects, this delay was found between 60 and 100 msec. In the patients, it was prolonged to 80-140 msec. This prolongation was closely related to the VEP latency (P100). Furthermore, visual suppression and the influence on it by different parameters were studied in detail in healthy subjects; the visual suppression depends on visual (e.g., brightness, duration) and magnetic (e.g., intensity) stimulus conditions. The method described seems to be of considerable value in the investigation of basic mechanisms of visual perception. This includes pathophysiological changes caused by optic neuritis and possibly other disorders affecting the visual system.
引用
收藏
页码:259 / 267
页数:9
相关论文
共 16 条
  • [1] SUPPRESSION OF VISUAL-PERCEPTION BY MAGNETIC COIL STIMULATION OF HUMAN OCCIPITAL CORTEX
    AMASSIAN, VE
    CRACCO, RQ
    MACCABEE, PJ
    CRACCO, JB
    RUDELL, A
    EBERLE, L
    [J]. ELECTROENCEPHALOGRAPHY AND CLINICAL NEUROPHYSIOLOGY, 1989, 74 (06): : 458 - 462
  • [2] TRANSCRANIAL MAGNETIC STIMULATION CAN INFLUENCE THE SELECTION OF MOTOR PROGRAMS
    AMMON, K
    GANDEVIA, SC
    [J]. JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY, 1990, 53 (08) : 705 - 707
  • [3] BARKER AT, 1985, J PHYSIOL-LONDON, V369, pP3
  • [4] TRANSCRANIAL MAGNETIC STIMULATION OF THE HUMAN-BRAIN - RESPONSES IN MUSCLES SUPPLIED BY CRANIAL NERVES
    BENECKE, R
    MEYER, BU
    SCHONLE, P
    CONRAD, B
    [J]. EXPERIMENTAL BRAIN RESEARCH, 1988, 71 (03) : 623 - 632
  • [5] STIMULATION OF MOTOR TRACTS IN MOTOR-NEURON DISEASE
    BERARDELLI, A
    INGHILLERI, M
    FORMISANO, R
    ACCORNERO, N
    MANFREDI, M
    [J]. JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY, 1987, 50 (06) : 732 - 737
  • [6] VARIABILITY OF CORTICALLY EVOKED MOTOR-RESPONSES IN MULTIPLE-SCLEROSIS
    BRITTON, TC
    MEYER, BU
    BENECKE, R
    [J]. ELECTROENCEPHALOGRAPHY AND CLINICAL NEUROPHYSIOLOGY, 1991, 81 (03): : 186 - 194
  • [7] CLAUS D, 1988, EXP BRAIN RES, V71, P273
  • [8] DELAY IN THE EXECUTION OF VOLUNTARY MOVEMENT BY ELECTRICAL OR MAGNETIC BRAIN-STIMULATION IN INTACT MAN - EVIDENCE FOR THE STORAGE OF MOTOR PROGRAMS IN THE BRAIN
    DAY, BL
    ROTHWELL, JC
    THOMPSON, PD
    DENOORDHOUT, AM
    NAKASHIMA, K
    SHANNON, K
    MARSDEN, CD
    [J]. BRAIN, 1989, 112 : 649 - 663
  • [9] MAGNETIC BRAIN-STIMULATION - CENTRAL MOTOR CONDUCTION STUDIES IN MULTIPLE-SCLEROSIS
    HESS, CW
    MILLS, KR
    MURRAY, NMF
    SCHRIEFER, TN
    [J]. ANNALS OF NEUROLOGY, 1987, 22 (06) : 744 - 752
  • [10] CENTRAL MOTOR CONDUCTION IN MULTIPLE-SCLEROSIS - EVALUATION OF ABNORMALITIES REVEALED BY TRANS-CUTANEOUS MAGNETIC STIMULATION OF THE BRAIN
    INGRAM, DA
    THOMPSON, AJ
    SWASH, M
    [J]. JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY, 1988, 51 (04) : 487 - 494