DEPRESSED SERUM ERYTHROPOIETIN IN PREGNANT-WOMEN WITH ELEVATED BLOOD LEAD

被引：28

作者：

GRAZIANO, JH

SLAVKOVIC, V

FACTORLITVAK, P

POPOVAC, D

AHMEDI, X

MEHMETI, A

机构：

[1] UNIV PRISTINA, PRISTINA, YUGOSLAVIA

[2] MED CTR, TITOVA MITROVICA, YUGOSLAVIA

来源：

ARCHIVES OF ENVIRONMENTAL HEALTH | 1991年 / 46卷 / 06期

关键词：

D O I：

10.1080/00039896.1991.9934401

中图分类号：

X [环境科学、安全科学];

学科分类号：

08 ; 0830 ;

摘要：

During the course of a prospective study of lead exposure and pregnancy outcome in 1502 women, we tested the hypothesis that environmental lead exposure is associated with depressed serum erythropoietin concentration. At mid-pregnancy and at delivery, blood samples were stratified by hemoglobin concentration; within each hemoglobin stratum, sera of women with the lowest and highest whole blood lead concentrations were selected for serum erythropoietin analysis. Analysis of variance revealed that women with higher blood lead levels had inappropriately low serum erythropoietin at both mid-pregnancy and at delivery. Thus, depressed serum erythropoietin appears to indicate lead nephrotoxicity, and it may also be responsible for the anemia associated with lead poisoning.

引用

页码：347 / 350

页数：4

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