AMPLIFIED BCL-2/JH REARRANGEMENTS IN REACTIVE LYMPHADENOPATHY

被引：11

作者：

OHSHIMA, K ^{[1
]}

KIKUCHI, M ^{[1
]}

KOBARI, S ^{[1
]}

MASUDA, Y ^{[1
]}

EGUCHI, F ^{[1
]}

KIMURA, N ^{[1
]}

机构：

[1] FUKUOKA UNIV,SCH MED,DEPT INTERNAL MED 1,FUKUOKA 81401,JAPAN

来源：

VIRCHOWS ARCHIV B-CELL PATHOLOGY INCLUDING MOLECULAR PATHOLOGY | 1993年 / 63卷 / 03期

关键词：

BCL-2; REACTIVE LYMPHADENOPATHY;

D O I：

10.1007/BF02899261

中图分类号：

R36 [病理学];

学科分类号：

100104 ;

摘要：

Using the polymerase chain reaction (PCR) to examine the occurrence of bcl-2/JH joining produced by t(14;18) chromosomal translocation, amplified DNA was detected in 2 of 18 lymph nodes showing reactive lymphadenopathy. The PCR was repeated in these two lymphs nodes using the same DNA samples, but no amplification was detected at the second attempt. Thus the amplified DNA was considered to be derived from one copy of joined bcl-2/JH in one cell, or from a few copies in a few clonal cells with the same joined bcl-2/JH. These results suggest that false joining of bcl-2/JH at the t(14;18) junction may occur in reactive lymph nodes.

引用

页码：197 / 198

页数：2