Lipoprotein(a) stimulates the proliferation of cultured human arterial smooth muscle cells through two pathways

被引：18

作者：

Miyata, M ^{[1
]}

Biro, S ^{[1
]}

Kaieda, H ^{[1
]}

Tanaka, H ^{[1
]}

机构：

[1] KAGOSHIMA UNIV,FAC MED,DEPT INTERNAL MED 1,KAGOSHIMA 890,JAPAN

来源：

FEBS LETTERS | 1995年 / 377卷 / 03期

关键词：

lipoprotein(a); smooth muscle cell; transforming growth factor-beta;

D O I：

10.1016/0014-5793(95)01404-7

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

We investigated the effect of lipoprotein(a) (Lp(a)) on proliferation of human arterial smooth muscle cells (SMCs) and its mechanisms of action. Low density lipoprotein (LDL), Lp(a) and apolipoprotein(a) (apo(a)) significantly stimulated the proliferation of SMCs. Lp(a) and apo(a) reduced the amount of active transforming growth factor-beta (TGF-beta) with the mink lung epithelial cell bioassay, however LDL had no effect. Lp(a), but not apo(a), significantly stimulated the proliferation of SMCs even in the presence of a neutralizing antibody for TGF-beta. Our results suggest that Lp(a) stimulates the proliferation of SMCs via apo(a)-induced inhibition of TGF-beta activation and stimulation of SMCs by the LDL-particle of Lp(a).

引用

页码：493 / 496

页数：4

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