PSYCHOACTIVE MEDICATIONS AND INJURIOUS MOTOR-VEHICLE COLLISIONS INVOLVING OLDER DRIVERS

被引：151

作者：

LEVEILLE, SG

BUCHNER, DM

KOEPSELL, TD

MCCLOSKEY, LW

WOLF, ME

WAGNER, EH

机构：

[1] Department of Epidemiology, Seattle, WA

[2] Center for Health Studies, Group Health Cooperative of Puget Sound, Seattle, WA

[3] Department of Health Services, University of Washington, Seattle, WA

[4] Health Services Research, Seattle Veterans Administration Medical Center, Seattle, WA

[5] Harborview Injury Prevention and Research Center, Seattle, WA

来源：

EPIDEMIOLOGY | 1994年 / 5卷 / 06期

关键词：

TRAFFIC ACCIDENTS; ADDICTIVE ANALGESICS; ANTIDEPRESSIVE AGENTS; BENZODIAZEPINES; HISTAMINE H-1 RECEPTOR BLOCKADERS; NARCOTICS; PSYCHOTROPIC DRUGS; AGED;

D O I：

10.1097/00001648-199411000-00006

中图分类号：

R1 [预防医学、卫生学];

学科分类号：

1004 ; 120402 ;

摘要：

Older drivers have the second highest risk for motor vehicle collisions of any age group, after adolescents. Psychoactive medications may place older drivers at increased risk for injurious motor vehicle collisions. We conducted a population-based matched case-control study of older drivers who were involved in injurious crashes during 1987 and 1988. The 234 cases and 447 controls were members of a large Seattle-based health maintenance organization. Use of anti depressants and opioid analgesics by older drivers was associated with increased risk for injurious motor vehicle collisions. Compared with non-users, current users of cyclic antidepressants had an adjusted relative risk (RR) of 2.3 [95% confidence interval (CI) = 1.1-4.8]. Opioid analgesic use was also associated with an elevated crash risk (adjusted RR = 1.8; 95% CI = 1.0-3.4). We found no evidence of a dose-related effect with either class of drug. Current use of benzodiazepines or sedating antihistamines had little association with increased risk for injurious collisions.

引用

页码：591 / 598

页数：8

共 26 条

[1]

Williams A.F., Carsten O., Driver age and crash involvement, Am J Public Health, 79, pp. 326-327, (1989)

[2]

Rice D.P., MacKenzie E.J., Et al., Cost of Injury in the United States: A Report to Congress, (1989)

[3]

Pemeger T., Smith G.S., The driver’s role in fatal two-car crashes: A paired “case-control” study, Am J Epidemiol, 134, pp. 1138-1145, (1991)

[4]

Ray W.A., Fought R.L., Decker M.D., Psychoactive drugs and the risk of injurious motor vehicle crashes in elderly drivers, Am J Epidemiol, 136, pp. 873-883, (1992)

[5]

Hindmarch I., The psychopharmacological approach: Effects of psychotropic drugs on car handling, Int Clin Psychopharm, 3, pp. 74-79, (1988)

[6]

Gengo F., Gabos C., Miller J.K., The pharmacodynamics of diphenhydramine-induced drowsiness and changes in mental performance, Clin Pharmacol Ther, 45, pp. 15-21, (1989)

[7]

Seppala T., Linnoila M., Mattila M.J., Drugs, alcohol, and driving, Drugs, 17, pp. 389-408, (1979)

[8]

Koepsell T.D., Wolf M., McCloskey L., Buchner D.M., Louie D., Wagner E.H., Medical conditions and motor vehicle collision injuries in older adults, J am Geriatr Soc, 42, pp. 695-700, (1994)

[9]

Von Korff M., Wagner E.H., Sanders K., A chronic disease score from automated pharmacy data, J Clin Epidemiol, 45, pp. 197-203, (1992)

[10]

Goodman G.A.G., Rall T.W., Nies A.S., Taylor P., The Pharmacological Basis of Therapeutics, pp. 411-497, (1990)

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