SINGLET MOLECULAR-OXYGEN IN THE HABER-WEISS REACTION

被引：182

作者：

KHAN, AU

KASHA, M

机构：

[1] FLORIDA STATE UNIV, INST MOLEC BIOPHYS, TALLAHASSEE, FL 32306 USA

[2] FLORIDA STATE UNIV, DEPT CHEM, TALLAHASSEE, FL 32306 USA

来源：

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | 1994年 / 91卷 / 26期

关键词：

SUPEROXIDE DISMUTASE; PEROXIDE CLEAVAGE; ELECTRON TRANSFER;

D O I：

10.1073/pnas.91.26.12365

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Characteristic chemiluminescence emission of singlet ((1) Delta(g)) molecular oxygen at 1268 nm is reported from a Haber-Weiss reaction. The reaction consists of mixing aqueous hydrogen peroxide with a solution of potassium superoxide, solubilized by 18-crown-6 ether in carbon tetrachloride or in dry acetonitrile at room temperature. Since the discovery of the enzyme superoxide dismutase by J. M. McCord and I. Fridovich [(1968) J. Biol. Chem. 243, 5733-5760], the identity of the reactive oxidant in superoxide-generating systems in biology has remained a chemical mystery. The results presented here suggest strongly that the reactive species is singlet oxygen generated via the Haber-Weiss reaction and not, as usually assumed, the hydroxyl radical, (OH)-O-., generated by the same reaction.

引用

页码：12365 / 12367

页数：3

共 21 条

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