INSULIN GENE ENHANCER BINDING-PROTEIN ISL-1 IS A MEMBER OF A NOVEL CLASS OF PROTEINS CONTAINING BOTH A HOMEODOMAIN AND A CYS-HIS DOMAIN

被引：650

作者：

KARLSSON, O ^{[1
]}

THOR, S ^{[1
]}

NORBERG, T ^{[1
]}

OHLSSON, H ^{[1
]}

EDLUND, T ^{[1
]}

机构：

[1] UMEA UNIV,DEPT MICROBIOL,S-90187 UMEA,SWEDEN

来源：

NATURE | 1990年 / 344卷 / 6269期

关键词：

D O I：

10.1038/344879a0

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

THE activity of the rat insulin I gene enhancer is mainly dependent on two cis-acting protein-binding domains1-3. Here we report the isolation of a complementary DNA encoding a protein, Isl-1, that binds to one of these domains. Isl-1 contains a homeodomain with greatest similarity to those of the Caenorhabditis elegans proteins encoded by mec-3 (ref. 4) and lin-11 (ref. 5). In addition, Isl-1, like the lin-11 and mec-3 gene products, contains a novel Cys-His domain which is reminiscent of known metal-binding regions. Together these proteins define a novel class of proteins containing both a homeo- and a Cys His-domain. Isl-1 is preferentially expressed in cells of pancreatic endocrine origin. If the structural homologies between Isl-1 and the C. elegans gene products reflect functional similarities, a role for Isl-1 in the development of pancreatic endocrine cells could be envisaged. © 1990 Nature Publishing Group.

引用

页码：879 / 882

页数：4

共 21 条

[1] HYBRID INSULIN GENES REVEAL A DEVELOPMENTAL LINEAGE FOR PANCREATIC ENDOCRINE-CELLS AND IMPLY A RELATIONSHIP WITH NEURONS [J].