HUMAN-IMMUNODEFICIENCY-VIRUS TYPE-1 SEROCONVERSION IN WOMEN WITH GENITAL ULCERS

被引:81
作者
PLOURDE, PJ
PEPIN, J
AGOKI, E
RONALD, AR
OMBETTE, J
TYNDALL, M
CHEANG, M
NDINYAACHOLA, JO
DCOSTA, LJ
PLUMMER, FA
机构
[1] UNIV NAIROBI,DEPT MED MICROBIOL,WHO,CTR RES & TRAINING SEXUALLY TRANSMITTED DIS,NAIROBI,KENYA
[2] NAIROBI CITY COMMISS,SPECIAL TREATMENT CLIN,NAIROBI,KENYA
[3] UNIV MANITOBA,DEPT INTERNAL MED,WINNIPEG R3T 2N2,MB,CANADA
[4] UNIV MANITOBA,DEPT MED MICROBIOL,WINNIPEG R3T 2N2,MB,CANADA
基金
英国医学研究理事会;
关键词
D O I
10.1093/infdis/170.2.313
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
Genital ulcers are implicated as a risk factor enhancing susceptibility to human immunodeficiency virus type 1 (HIV-1) infection. A prospective study to determine the incidence of and risk factors associated with acquisition of HIV-1 in women with genital ulcers was done. HIV-1-seronegative women with genital ulcers attending a clinic for sexually transmitted diseases in Nairobi were followed to HIV-1 seroconversion over a 6-month period. Of 81 women, 10 seroconverted to HIV-1. The crude 6-month incidence of HIV-1 infection was 12%. Risk factors associated with seroconversion included cervical ectopy (rate ratio [RR], 4.9; 95% confidence interval [CI], 1.5-15.6) and pelvic inflammatory disease (RR, 6.3; 95% CI, 1.9-20.4). Thus, cervical ectopy and pelvic inflammatory disease may increase susceptibility to HIV-1 in women with genital ulcers.
引用
收藏
页码:313 / 317
页数:5
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