TRANSDERMAL NITROGLYCERIN PREVENTS NONSTEROIDAL ANTIINFLAMMATORY DRUG GASTROPATHY

被引：14

作者：

BARRACHINA, MD ^{[1
]}

CALATAYUD, S ^{[1
]}

CANET, A ^{[1
]}

BELLO, R ^{[1
]}

DEROJAS, FD ^{[1
]}

GUTH, PH ^{[1
]}

ESPLUGUES, JV ^{[1
]}

机构：

[1] UNIV VALENCIA,FAC MED,DEPT FARMACOL,E-46010 VALENCIA,SPAIN

来源：

EUROPEAN JOURNAL OF PHARMACOLOGY | 1995年 / 281卷 / 02期

关键词：

NSAID (NONSTEROIDAL ANTIINFLAMMATORY DRUG); GASTRIC MUCOSAL INJURY; NITRIC OXIDE (NO);

D O I：

10.1016/0014-2999(95)00399-6

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The application of a transdermal nitroglycerin patch (2-30 mu g/3 h/rat) protected, in a dose-dependent manner, the rat gastric mucosa against damage induced by the nonsteroidal anti-inflammatory agent indomethacin (20 mg/kg s.c.).

引用

页码：R3 / R4

页数：2

共 5 条

[1] NITRIC-OXIDE DONORS INCREASE MUCUS GEL THICKNESS IN RAT STOMACH [J].

BROWN, JF ;

HANSON, PJ ;

WHITTLE, BJR .

EUROPEAN JOURNAL OF PHARMACOLOGY, 1992, 223 (01) :103-104

[2] NITRIC-OXIDE - AN ENDOGENOUS MODULATOR OF LEUKOCYTE ADHESION [J].

KUBES, P ;

SUZUKI, M ;

GRANGER, DN .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1991, 88 (11) :4651-4655

[3] THE ACTIONS OF NITRIC-OXIDE DONORS IN THE PREVENTION OR INDUCTION OF INJURY TO THE RAT GASTRIC-MUCOSA [J].

LOPEZBELMONTE, J ;

WHITTLE, BJR ;

MONCADA, S .

BRITISH JOURNAL OF PHARMACOLOGY, 1993, 108 (01) :73-78

[4] THE VASODILATOR ROLE OF ENDOGENOUS NITRIC-OXIDE IN THE RAT GASTRIC MICROCIRCULATION [J].

PIQUE, JM ;

WHITTLE, BJR ;

ESPLUGUES, JV .

EUROPEAN JOURNAL OF PHARMACOLOGY, 1989, 174 (2-3) :293-296

[5] A DICLOFENAC DERIVATIVE WITHOUT ULCEROGENIC PROPERTIES [J].

WALLACE, JL ;

REUTER, B ;

CICALA, C ;

MCKNIGHT, W ;

GRISHAM, M ;

CIRINO, G .

EUROPEAN JOURNAL OF PHARMACOLOGY, 1994, 257 (03) :249-255

← 1 →