CLINICAL PHARMACOKINETICS OF NEW ANTIEPILEPTIC DRUGS

被引：107

作者：

WALKER, MC ^{[1
]}

PATSALOS, PN ^{[1
]}

机构：

[1] UNIV LONDON, INST NEUROL, DEPT CLIN NEUROL, EPILEPSY RES GRP, LONDON WC1N 3BG, ENGLAND

来源：

PHARMACOLOGY & THERAPEUTICS | 1995年 / 67卷 / 03期

关键词：

EPILEPSY; NEW ANTIEPILEPTIC DRUGS; PHARMACOKINETICS; CONTROLLED-RELEASE; PRODRUGS;

D O I：

10.1016/0163-7258(95)00021-6

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

We have reviewed the pharmacokinetics of six antiepileptic drugs that are marketed (felbamate, gabapentin, lamotrigine, oxcarbazepine, vigabatrin, and zonisamide) and six drugs that are undergoing evaluation (levetiracetam, ralitoline, remacemide, stiripentol, tiagabine, and topiramate). In addition, we have compared the prodrugs eterobarb and fosphenytoin and the controlled-release formulations of valproic acid and carbamazepine with their parent compounds. Finally, we have devised a scoring system to compare the pharmacokinetics of new antiepileptic drugs. Using this system, vigabatrin, levetiracetam, gabapentin, and topiramate appear to have the most favourable pharmacokinetic profiles, whilst ralitoline and stiripentol have the least favourable.

引用

页码：351 / 384

页数：34

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