TOLERABILITY AND KINETICS OF A SOLVENT-DETERGENT-TREATED INTRAVENOUS IMMUNOGLOBULIN PREPARATION IN HYPOGAMMAGLOBULINEMIA PATIENTS

被引：12

作者：

EBELING, F

BAER, M

HORMILA, P

JARVENTIE, G

KOISTINEN, P

KATKA, K

OKSANEN, K

PERKKIO, M

RUUTU, T

SOPPI, E

VEIJOLA, L

MYLLYLA, G

机构：

[1] TAMPERE UNIV,CENT HOSP,SF-33520 TAMPERE,FINLAND

[2] JORVI HOSP,SF-02740 ESPOO,FINLAND

[3] UNIV OULU,CENT HOSP,SF-90220 OULU,FINLAND

[4] KANTA HAME CENT HOSP,HAMEENLINNA,FINLAND

[5] KUOPIO UNIV HOSP,SF-70210 KUOPIO,FINLAND

[6] LAAKSO AURORA HOSP,HELSINKI,FINLAND

[7] HELSINKI UNIV,CENT HOSP,HELSINKI,FINLAND

来源：

VOX SANGUINIS | 1995年 / 69卷 / 02期

关键词：

D O I：

10.1111/j.1423-0410.1995.tb01675.x

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The tolerability and kinetics of a solvent-detergent-treated 6% intravenous immunoglobulin (IVIG) preparation were studied in 15 hypogammaglobulinaemia patients during 3-4 regular substitution infusions of 9-48 g, the mean dose being 359 mg/kg. The infusions were well tolerated, and the trough serum IgG levels achieved were comparable to two commercial IVIG preparations. The stepwise increase of the infusion rate up to 5 mg/kg/min and the use of this IVIG as a 12% solution were possible without serious adverse events in all the 6 studied hypogammaglobulinaemia patients. This greatly reduced the time needed for the infusions.

引用

页码：91 / 94

页数：4

共 15 条

[1] INTRAVENOUS ADMINISTRATION OF HUMAN GAMMA-GLOBULIN [J].