THE IMPACT OF PERITONEAL TRAUMA ON INTRAABDOMINAL FIBRINOLYTIC-ACTIVITY, ADHESION FORMATION AND EARLY EMBRYONIC-DEVELOPMENT IN A RABBIT LONGITUDINAL MODEL

被引：9

作者：

BOUCKAERT, PXJM

LAND, JA

BROMMER, EJP

EMEIS, JJ

EVERS, JLH

机构：

[1] Department of Obstetrics and Gynaecology, University Hospital, NL-6201 BX Maastricht

[2] Gaubius Institute TNO, Research Centrefor Fibrinolysis, Thrombolyis Herenstraat 5d

来源：

HUMAN REPRODUCTION | 1990年 / 5卷 / 03期

关键词：

Adhesions; Embryo; Fibrinolysis; Peritoneum; Trauma;

D O I：

10.1093/oxfordjournals.humrep.a137079

中图分类号：

R71 [妇产科学];

学科分类号：

100211 ;

摘要：

Intra-abdominal adhesions may interfere with fertility following gynaecological surgery and injury to the peritoneum plays a central role in the pathogenesis. Tissue plasminogen activator and its antagonists play a pivotal role in the intra-abdominal balance between fibrinolysis and adhesion formation. This process may be cycle-dependent in women. In order to establish the impact of the fibrinolytic activity on adhesion formation after a standardized trauma, a rabbit longitudinal model was developed, which allowed the study of possible differences between the periods before and after ovulation. The influence of extra-genital adhesions on early embryonic development was investigated. No cycle-dependent changes in fibrinolytic activity of the peritoneal fluid (PF) or of the serum could be demonstrated. No correlation was found between post-operative adhesion formation and the fibrinolytic activity during surgery. Three weeks after surgery, a significant increase in fibrinolytic activity of the PF was observed. The rank order of sampling is suggested to account for these differences. Extra-genital adhesions did not markedly influence ovulation, ovum pick-up and fertilization in this hormonally controlled rabbit model. © 1990 Oxford University Press.

引用

页码：237 / 241

页数：5

共 23 条

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