THE SKIN HYPEREMIC RESPONSE TO LOCAL INJECTION OF SUBSTANCE-P AND CAPSAICIN IN DIABETES-MELLITUS

被引：17

作者：

BOOLELL, M ^{[1
]}

TOOKE, JE ^{[1
]}

机构：

[1] CHARING CROSS HOSP,DEPT PHYSIOL,LONDON W6 8RP,ENGLAND

来源：

DIABETIC MEDICINE | 1990年 / 7卷 / 10期

关键词：

Capsaicin; Diabetes mellitus; Laser Doppler flowmetry; Skin hyperaemia; Substance P;

D O I：

10.1111/j.1464-5491.1990.tb01325.x

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Recent studies have demonstrated impaired skin hyperaemia to local injury in diabetes mellitus. In order to gain insight into the mechanisms of impaired hyperaemia, dose‐response curves to intradermal substance P (25, 50, 100 pmol) and capsaicin (1.0, 2.5, 5.0 nmol) were examined before and after histamine blockade with chlorpheniramine, in 6 patients with uncomplicated Type 1 diabetes and 9 matched control subjects. Skin hyperaemia was measured indirectly as the peak laser Doppler flow in proximity to the area of hyperaemia. The response to the three doses of substance P was significantly lower in diabetic patients (0.37 ± 0.12 (± SD), 0.51 ± 0.12, 0.67 ± 0.09 V) than in control subjects (0.57 ± 0.15, 0.70 ± 0.19, 0.84 ± 0.21 V; p < 0.01). In contrast there was no significant difference in skin hyperaemia to capsaicin between diabetic patients (0.41 ± 0.07, 0.50 ± 0.09, 0.59 ± 0.09 V) and control subjects (0.41 ± 0.06, 0.52 ± 0.08, 0.63 ± 0.07 V). Following chlorpheniramine, the response to capsaicin remained unaltered (0.39 ± 0.07, 0.51 ± 0.05, 0.60 ± 0.07 in diabetic patients and 0.43 ± 0.08, 0.50 ± 0.10, 0.63 ± 0.07 V in control subjects), but there was a significant reduction in hyperaemia to substance P in both patients (20.4 ± 12.3% reduction, p < 0.05) and control subjects (20.6 ± 14.1% reduction, p < 0.05). It is suggested that impaired skin hyperaemia may represent decreased vascular reactivity to locally released substance P from peripheral nerve fibres. 1990 Diabetes UK

引用

页码：898 / 901

页数：4

共 20 条

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