A CONVENIENT PREPARATION OF PROTECTED 2'-O-METHYLGUANOSINE

被引：8

作者：

LEONARD, TE ^{[1
]}

BHAN, P ^{[1
]}

MILLER, PS ^{[1
]}

机构：

[1] JOHNS HOPKINS UNIV,SCH HYG & PUBL HLTH,DEPT BIOCHEM,BALTIMORE,MD 21205

来源：

NUCLEOSIDES & NUCLEOTIDES | 1992年 / 11卷 / 06期

关键词：

D O I：

10.1080/07328319208018335

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Protected guanosine nucleosides can be converted directly to their 2'-O-methyl derivatives by methylation with trimethylsilyldiazomethane in the presence of stannous chloride. This procedure circumvents the need to use the potentially hazardous reagent, diazomethane.

引用

页码：1201 / 1204

页数：4

共 9 条

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