TEMPORAL RELATIONSHIP OF ACINAR AND MICROVASCULAR CHANGES IN CERULEIN-INDUCED PANCREATITIS

被引:7
作者
KELLY, DM
MCENTEE, GP
DELANEY, C
MCGEENEY, KF
FITZPATRICK, JM
机构
[1] MATER MISERICORDIAE HOSP,DEPT SURG,47 ECCLES ST,DUBLIN 7,IRELAND
[2] NATL UNIV IRELAND UNIV COLL DUBLIN,DEPT MED & THERAPEUT,DUBLIN 4,IRELAND
关键词
D O I
10.1002/bjs.1800800936
中图分类号
R61 [外科手术学];
学科分类号
摘要
A study in rats investigated the temporal relationship between acinar cell changes and alterations in the local microvasculature in oedematous pancreatitis produced by administration of caerulein 5 mug kg-1 h-1. Samples were taken from experimental and control animals after 15 min, 30 min, 1 h and 2 h of caerulein infusion. Transmission electron microscopy showed ultrastructural acinar cell changes after 15 min whereas the earliest microvascular changes were seen after 30 min. Ultrastructural alterations in the acinar cells thus preceded local microvascular changes. Microvascular distortion appears to be a consequence and not a cause of pancreatitis in the caerulein model.
引用
收藏
页码:1174 / 1176
页数:3
相关论文
共 11 条
[1]  
ADLER G, 1986, EXOCRINE PANCREAS BI, P405
[2]   EVIDENCE OF INTRACELLULAR ACTIVATION OF SERINE PROTEASES IN ACUTE CERULEIN-INDUCED PANCREATITIS IN RATS [J].
BIALEK, R ;
WILLEMER, S ;
ARNOLD, R ;
ADLER, G .
SCANDINAVIAN JOURNAL OF GASTROENTEROLOGY, 1991, 26 (02) :190-196
[3]   HEMODYNAMIC CONSEQUENCES OF SEVERE PANCREATITIS [J].
BRADLEY, EL ;
HALL, JR ;
LUTZ, J ;
HAMNER, L ;
LATTOUF, O .
ANNALS OF SURGERY, 1983, 198 (02) :130-133
[4]   THE EFFECT OF CERULEIN INDUCED PANCREATITIS ON THE HEPATIC MICROVASCULATURE [J].
DELANEY, C ;
MCENTEE, G ;
COTTELL, D ;
MCGEENEY, K ;
FITZPATRICK, JM .
BRITISH JOURNAL OF SURGERY, 1990, 77 (03) :294-296
[5]   PANCREATIC ISCHEMIA IN EXPERIMENTAL ACUTE-PANCREATITIS - MECHANISM, SIGNIFICANCE AND THERAPY [J].
KLAR, E ;
MESSMER, K ;
WARSHAW, AL ;
HERFARTH, C .
BRITISH JOURNAL OF SURGERY, 1990, 77 (11) :1205-1210
[6]   3-DIMENSIONAL MORPHOLOGICAL-STUDY OF THE PANCREATIC MICROVASCULATURE IN CAERULEIN-INDUCED EXPERIMENTAL PANCREATITIS [J].
MCENTEE, G ;
LEAHY, A ;
COTTELL, D ;
DERVAN, P ;
MCGEENEY, K ;
FITZPATRICK, JM .
BRITISH JOURNAL OF SURGERY, 1989, 76 (08) :853-855
[7]  
MURESAN V, 1986, J SUBMICR CYTOL PATH, V18, P691
[8]  
SANFEY H, 1984, SURGERY, V96, P485
[9]   PANCREATIC MICROVASCULAR PERMEABILITY IN CERULEIN-INDUCED ACUTE-PANCREATITIS [J].
SWEIRY, JH ;
MANN, GE .
AMERICAN JOURNAL OF PHYSIOLOGY, 1991, 261 (04) :G685-G692
[10]  
TARDINI A, 1971, AM J PATHOL, V62, P35