SUMATRIPTAN AND CEREBRAL PERFUSION IN HEALTHY-VOLUNTEERS

被引：19

作者：

SCOTT, AK

GRIMES, S

NG, K

CRITCHLEY, M

BRECKENRIDGE, AM

THOMSON, C

PILGRIM, AJ

机构：

[1] UNIV LIVERPOOL,DEPT PHARMACOL & THERAPEUT,LIVERPOOL L69 3BX,ENGLAND

[2] ROYAL LIVERPOOL UNIV HOSP,DEPT NUCL MED,LIVERPOOL,ENGLAND

[3] GLAXO GRP RES LTD,GREENFORD UB6 0HE,MIDDX,ENGLAND

来源：

BRITISH JOURNAL OF CLINICAL PHARMACOLOGY | 1992年 / 33卷 / 04期

关键词：

SUMATRIPTAN; MIGRAINE; CEREBRAL PERFUSION;

D O I：

10.1111/j.1365-2125.1992.tb04058.x

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

1 The effect of sumatriptan on regional cerebral perfusion was studied in healthy volunteers. 2 Intravenous sumatriptan (2 mg) had not detectable effect on regional cerebral perfusion as measured using a SPECT system with 99technetium(m) labelled hexemethylpropyleneamineoxime. 3 Sumatriptan had not effect on pulse, blood pressure or ECG indices. 4 All six volunteers experienced minor adverse effects during the intravenous infusion.

引用

页码：401 / 404

页数：4

共 7 条

[1] THE SELECTIVE CAROTID ARTERIAL VASOCONSTRICTOR ACTION OF GR43175 IN ANESTHETIZED DOGS [J].