PROTEIN-LOSING ENTEROPATHY AND HYPOALBUMINEMIA IN AIDS

被引:33
作者
LAINE, L [1 ]
GARCIA, F [1 ]
MCGILLIGAN, K [1 ]
MALINKO, A [1 ]
SINATRA, FR [1 ]
THOMAS, DW [1 ]
机构
[1] CHILDRENS HOSP LOS ANGELES,LOS ANGELES,CA
关键词
AIDS; ALBUMIN; PROTEIN-LOSING ENTEROPATHY; DIARRHEA;
D O I
10.1097/00002030-199306000-00012
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
Objective: To assess the contribution of protein-losing enteropathy to AIDS-associated hypoalbuminemia. Design: Prospective assessment of patients with AIDS. Setting. An urban county hospital (Los Angeles & University of Southern California Medical Center. USA). Patients: Four groups of patients with AIDS were studied: (1) patients with normal serum albumin (greater-than-or-equal-to 3.9 g/dl) and normal bowel habits; (2) patients with normal serum albumin and diarrhea (greater-than-or-equal-to four loose or watery stools per day for greater-than-or-equal-to 2 weeks); (3) patients with hypoalbuminemia (less-than-or-equal-to 3.0 g/dl) and normal bowel habits; and (4) patients with hypoalbuminemia and diarrhea. Main outcome measure: Fecal alpha1-antitrypsin concentration was used as a measure of protein loss in the gut. Results: Patients with hypoalbuminemia had a significantly higher mean fecal alpha1-antitrypsin concentration than those with normal albumin (10.8 +/- 3.0 mg/g dry stool versus 2.4 +/- 0.4 mg/g dry stool; P less-than-or-equal-to 0.001). Although mean fecal alpha1-antitrypsin concentrations were similar in patients with and without diarrhea in the normal albumin group, patients with hypoalbuminemia and diarrhea had signficantly higher levels of fecal alpha1-antitrypsin than those with hypoalbuminemia and normal bowel habits (17.3 +/- 5.8 mg/g dry stool versus 4.6 +/- 1.0 mg/g dry stool; P = 0.009). Twelve out of 36 (33%) patients with normal albumin had elevation of fecal alpha1-antitrypsin compared with 33 (70%) of 47 patients with hypoalbuminemia (P less-than-or-equal-to 0.001). Linear regression analysis showed a significant negative correlation between serum albumin and fecal alpha1-antitrypsin concentration (r = -0.38; P less-than-or-equal-to 0.001). Fecal alpha1-antitrypsin was significantly higher in patients with mucosal disease visualized at upper endoscopy or flexible sigmoidoscopy than in those without gross abnormalities (13.5 +/- 5.8 mg/g dry stool versus 2.4 +/- 0.7 mg/g dry stool; P = 0.005). Conclusion: Protein-losing enteropathy is common in patients with AIDS and may contribute to the development of hypoalbuminemia in these patients.
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页码:837 / 840
页数:4
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