THE STATISTICAL POWER OF [O-15]-WATER PET ACTIVATION STUDIES OF COGNITIVE-PROCESSES

被引：8

作者：

KAPUR, S

HUSSEY, D

WILSON, D

HOULE, S

机构：

[1] PET Centre, The Clarke Institute of Psychiatry, University of Toronto, Toronto, ON, M5T 1R8

来源：

NUCLEAR MEDICINE COMMUNICATIONS | 1995年 / 16卷 / 09期

关键词：

D O I：

10.1097/00006231-199509000-00009

中图分类号：

R8 [特种医学]; R445 [影像诊断学];

学科分类号：

1002 ; 100207 ; 1009 ;

摘要：

[O-15]-Water positron emission tomography (PET) scanning is an important means of investigating the neural correlates of cognitive processes. This study analyses the statistical power of these experiments under usual experimental conditions. Eleven subjects were scanned repeatedly while they undertook an active-baseline task. Using an empirically derived estimate of variance, the statistical power to detect task-induced increases in regional cerebral blood flow was calculated for different values of magnitude of change, number of subjects and probability of Type I error. The results (a) provide an empirical basis for selecting the number of subjects for cognitive studies using [O-15]-water PET; (b) illustrate the importance of considering the statistical power of the test, while making a physiological interpretation of the results; and (c) highlight the problems in concluding the non-involvement of a given brain region in a cognitive task, based solely on the results of a PET study.

引用

页码：779 / 784

页数：6

共 32 条

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