Structure and function of 5S rRNA in the ribosome

被引：47

作者：

Bogdanov, AA

Dontsova, OA

Dokudovskaya, SS

Lavrik, IN

机构：

[1] Department of Chemistry of Natural Compounds, School of Chemistry, Moscow State University

来源：

BIOCHEMISTRY AND CELL BIOLOGY | 1995年 / 73卷 / 11-12期

关键词：

58; rRNA; ribosomes; 23S rRNA; site-directed chemical cross-linking; RNA folding;

D O I：

10.1139/o95-094

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

5S rRNA is a small RNA molecule that is a component of a ribosome from almost all living organisms. In this review, we discuss the biogenesis of 5S rRNA and its properties as an independent structural domain of a ribosome as well as the current concepts concerning the higher order structure of 5S rRNA in free state and in its complexes with ribosomal proteins and its folding in the ribosome. Special attention is paid to recent experimental approaches that have been useful in 5S rRNA studies. Our own data on topography of 5S rRNA in the ribosomes are discussed in detail. The hypothesis describing the possible functional role of 5S rRNA for ribosome functioning is discussed.

引用

页码：869 / 876

页数：8

共 60 条

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