HYALURONIDASE-INDUCED REDUCTIONS IN MYOCARDIAL INFARCT SIZE

被引：112

作者：

MACLEAN, D

FISHBEIN, MC

MAROKO, PR

BRAUNWALD, E

机构：

[1] HARVARD UNIV, SCH MED, DEPT MED, BOSTON, MA 02115 USA

[2] HARVARD UNIV, SCH MED, DEPT PATHOL, BOSTON, MA 02115 USA

[3] PETER BENT BRIGHAM HOSP, BOSTON, MA 02115 USA

来源：

SCIENCE | 1976年 / 194卷 / 4261期

关键词：

D O I：

10.1126/science.959848

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The size of myocardial infarctions following coronary artery occlusion in the rat was determined directly by measurement of creatine phosphokinase activity in homogenized whole left ventricles and by planimetric measurement of the area of the infarctions in histologic sections of serial slices of the left ventricles. Hyaluronidase produced significant reductions in expected infarct size both 48 h and 3 wk after occlusion without impairing fibrosis during the healing phase. The amount of myocardial necrosis that follows a coronary artery occlusion was directly amenable to reduction with a pharmacological intervention.

引用

页码：199 / 200

页数：2

共 12 条

[1] MECHANISM OF REDUCTION OF MYOCARDIAL INJURY BY HYALURONIDASE [J].