TYPE-I MACROPHAGE SCAVENGER RECEPTOR CONTAINS ALPHA-HELICAL AND COLLAGEN-LIKE COILED COILS

被引：926

作者：

KODAMA, T

FREEMAN, M

ROHRER, L

ZABRECKY, J

MATSUDAIRA, P

KRIEGER, M

机构：

[1] MIT,DEPT BIOL,CAMBRIDGE,MA 02139

[2] MASSACHUSETTS GEN HOSP,DEPT MED,BOSTON,MA 02114

[3] INTEGRATED GENET GENZYME,FRAMINGHAM,MA 01701

[4] WHITEHEAD INST BIOMED SCI,CAMBRIDGE,MA 02142

来源：

NATURE | 1990年 / 343卷 / 6258期

关键词：

D O I：

10.1038/343531a0

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The macrophage scavenger receptor is a trimeric membrane glycoprotein with unusual ligand-binding properties which has been implicated in the development of atherosclerosis. The trimeric structure of the bovine type I scavenger receptor, deduced by complementary DNA cloning, contains three extracellular C-terminal cysteine-rich domains connected to the transmembrane domain by a long fibrous stalk. This stalk structure, composed of an a-helical coiled coil and a collagen-like triple helix, has not previously been observed in an integral membrane protein. © 1990 Nature Publishing Group.

引用

收藏

页码：531 / 535

页数：5

相关论文

共 43 条

[1] STRUCTURE OF CANINE PULMONARY SURFACTANT APOPROTEIN - CDNA AND COMPLETE AMINO-ACID SEQUENCE [J].

BENSON, B ;

HAWGOOD, S ;

SCHILLING, J ;

CLEMENTS, J ;

DAMM, D ;

CORDELL, B ;

WHITE, RT .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1985, 82 (19) :6379-6383

[2] LIPOPROTEIN METABOLISM IN THE MACROPHAGE - IMPLICATIONS FOR CHOLESTEROL DEPOSITION IN ATHEROSCLEROSIS [J].

BROWN, MS ;

GOLDSTEIN, JL .

ANNUAL REVIEW OF BIOCHEMISTRY, 1983, 52 :223-261

[3] REVERSIBLE ACCUMULATION OF CHOLESTERYL ESTERS IN MACROPHAGES INCUBATED WITH ACETYLATED LIPOPROTEINS [J].

BROWN, MS ;

GOLDSTEIN, JL ;

KRIEGER, M ;

HO, YK ;

ANDERSON, RGW .

JOURNAL OF CELL BIOLOGY, 1979, 82 (03) :597-613

[4] ANTIATHEROGENIC EFFECT OF PROBUCOL UNRELATED TO ITS HYPOCHOLESTEROLEMIC EFFECT - EVIDENCE THAT ANTIOXIDANTS INVIVO CAN SELECTIVELY INHIBIT LOW-DENSITY-LIPOPROTEIN DEGRADATION IN MACROPHAGE-RICH FATTY STREAKS AND SLOW THE PROGRESSION OF ATHEROSCLEROSIS IN THE WATANABE HERITABLE HYPERLIPIDEMIC RABBIT [J].

CAREW, TE ;

SCHWENKE, DC ;

STEINBERG, D .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1987, 84 (21) :7725-7729

[5]

CHOMCZYNSKI P, 1987, ANAL BIOCHEM, V162, P156, DOI 10.1016/0003-2697(87)90021-2

[6] ALPHA-HELICAL COILED COILS AND BUNDLES - HOW TO DESIGN AN ALPHA-HELICAL PROTEIN [J].

COHEN, C ;

PARRY, DAD .

PROTEINS-STRUCTURE FUNCTION AND GENETICS, 1990, 7 (01) :1-15

[7] ACID-DEPENDENT LIGAND DISSOCIATION AND RECYCLING OF LDL RECEPTOR MEDIATED BY GROWTH-FACTOR HOMOLOGY REGION [J].

DAVIS, CG ;

GOLDSTEIN, JL ;

SUDHOF, TC ;

ANDERSON, RGW ;

RUSSELL, DW ;

BROWN, MS .

NATURE, 1987, 326 (6115) :760-765

[8]

DRICKAMER K, 1986, J BIOL CHEM, V261, P6878

[9] PROTEIN SERINE THREONINE KINASES [J].

EDELMAN, AM ;

BLUMENTHAL, DK ;

KREBS, EG .

ANNUAL REVIEW OF BIOCHEMISTRY, 1987, 56 :567-613

[10] MALONDIALDEHYDE ALTERATION OF LOW-DENSITY LIPOPROTEINS LEADS TO CHOLESTERYL ESTER ACCUMULATION IN HUMAN MONOCYTE-MACROPHAGES [J].

FOGELMAN, AM ;

SHECHTER, I ;

SEAGER, J ;

HOKOM, M ;

CHILD, JS ;

EDWARDS, PA .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES, 1980, 77 (04) :2214-2218

← 1 2 3 4 5 →