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STEREOSELECTIVE RADICAL-MEDIATED CYCLIZATION OF NOREPHEDRINE DERIVED ALPHA-IODOAMIDES - EXPERIMENTS AND TS-MODELING

被引：16
作者：
GENNARI, C
POLI, G
SCOLASTICO, C
VASSALLO, M
机构：
[1] Dipartimento di Chimica Organica e Industriale, Universilà di Milano, Centro CNR per lo Studio delle Sostanze Organiche Naturali, 20133 Milano
来源：
TETRAHEDRON-ASYMMETRY | 1991年 / 2卷 / 08期
关键词：
D O I：
10.1016/S0957-4166(00)80462-0
中图分类号：
O61 [无机化学];
学科分类号：
070301 ; 081704 ;
摘要：
Radical-mediated cyclization of norephedrine derived alpha-iodoamides 1 was found to be highly stereoselective (greater-than-or-equal-to 97:3) favouring diastereoisomer 2. Transition state modelling with a force field developed ad hoc, nicely predicts the stereochemical results.
引用
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页码：793 / 796
页数：4
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