ENHANCING FACTOR PROTEIN FROM MOUSE SMALL-INTESTINES BELONGS TO THE PHOSPHOLIPASE-A2 FAMILY

被引：33

作者：

MULHERKAR, R ^{[1
]}

RAO, R ^{[1
]}

RAO, L ^{[1
]}

PATKI, V ^{[1
]}

CHAUHAN, VS ^{[1
]}

DEO, MG ^{[1
]}

机构：

[1] INT CTR GENET ENGN & BIOTECHNOL,NEW DELHI,INDIA

来源：

FEBS LETTERS | 1993年 / 317卷 / 03期

关键词：

ENHANCING FACTOR; PLA2; EGF; RECEPTOR; PANETH CELL; HPLC;

D O I：

10.1016/0014-5793(93)81289-C

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Enhancing factor (EF), a growth regulatory molecule, isolated from mouse small intestines, has been well characterized in this laboratory. It increases the binding of epidermal growth factor in a unique manner via its own receptor. In the first 20 N-terminal amino acids sequenced, EF showed 50% homology to human Group II phospholipase A2 (PLA2). Here we propose that EF is yet another, unidentified isoform of PLA2 which regulates cell proliferation via modulation of EGF binding. To our knowledge, this is the first report implicating PLA2-II-like molecules in growth regulation.

引用

页码：263 / 266

页数：4

共 26 条

[1]

ARITA H, 1991, J BIOL CHEM, V266, P19139

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