ETHANOL CAN INHIBIT NITRIC-OXIDE PRODUCTION

被引：62

作者：

PERSSON, MG

GUSTAFSSON, LE

机构：

[1] KAROLINSKA INST,DEPT PHYSIOL,S-10401 STOCKHOLM 60,SWEDEN

[2] KAROLINSKA INST,INST ENVIRONM MED,S-10401 STOCKHOLM 60,SWEDEN

来源：

EUROPEAN JOURNAL OF PHARMACOLOGY | 1992年 / 224卷 / 01期

关键词：

NITRIC OXIDE (NO); ETHANOL; RESPIRATORY SYSTEM;

D O I：

10.1016/0014-2999(92)94826-H

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Endogenous nitric oxide (NO) in exhaled air from anaesthetized rabbits was monitored by chemiluminescence. Ethanol (3-30 mmol kg-1) infused i.v. dose dependently reduced the levels of exhaled NO, with an IC50 of 23 +/- 3 mmol kg-1. L-Arginine (1 g kg-1) did not reverse the effect of ethanol. These results demonstrate the inhibition of NO formation by ethanol in vivo.

引用

页码：99 / 100

页数：2

共 5 条

[1] CLONED AND EXPRESSED NITRIC-OXIDE SYNTHASE STRUCTURALLY RESEMBLES CYTOCHROME-P-450 REDUCTASE
BREDT, DS
HWANG, PM
GLATT, CE
LOWENSTEIN, C
REED, RR
SNYDER, SH
[J]. NATURE, 1991, 351 (6329) : 714 - 718
[2] ENDOGENOUS NITRIC-OXIDE IS PRESENT IN THE EXHALED AIR OF RABBITS, GUINEA-PIGS AND HUMANS
GUSTAFSSON, LE
LEONE, AM
PERSSON, MG
WIKLUND, NP
MONCADA, S
[J]. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1991, 181 (02) : 852 - 857
[3] MONCADA S, 1991, PHARMACOL REV, V43, P109
[4] NOWAK R, 1992, J NIH RES, V4, P49
[5] ENDOGENOUS NITRIC-OXIDE AS A PROBABLE MODULATOR OF PULMONARY CIRCULATION AND HYPOXIC PRESSOR-RESPONSE INVIVO
PERSSON, MG
GUSTAFSSON, LE
WIKLUND, NP
MONCADA, S
HEDQVIST, P
[J]. ACTA PHYSIOLOGICA SCANDINAVICA, 1990, 140 (04): : 449 - 457

← 1 →